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en Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: The objective of this study was to determine the levels of serum ischemia-modified albumin (IMA), fibrinogen (FIB) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) patients with hypertension (HT) (DMT2HTN) and without HT (DMT2). Also, their association with certain biochemical and physical factors were studied to identify possible risk factors that lead to cardiovascular complications. Methods: Fasting blood samples were collected from 35 DMT2 or DMT2HTN patients each to analyze differences in serum and plasma levels of IMA, hs-CRP, FIB, total cholesterol (TC), high and low density lipoproteins (HDL and LDL), triglyceride (TG), hemoglobin A1c (HbA1C), glycated hemoglobin and creatinine. Results: In DMT2 and DMT2HTN patients, IMA, hs-CRP, FIB, TC, TG, HDL, LDL, glycated hemoglobin and creatinine levels, including body mass index (BMI) and waist-to-hip ratio (WHR), were significantly higher relative to healthy controls. In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Lastly, both DMT2 and DMT2HTN patients demonstrated a significant reduction in HDL. Conclusions: DMT2 and DMT2HTN patients have a greater risk of developing cardiovascular related complications. This study suggests that quantifying hs-CRP, IMA and FIB levels can help diagnose the risk of developing complications during the early stages of metabolic and cardiovascular disease. Overall, the specific risk factors may be used for early identification of cardiovascular complications to decrease mortality and morbidity in T2DM patients.</div> Keywords: Diabetes Mellitus, Fibrinogen, Hemoglobin, High sensitivity C reactive proteins, Hypertension, Ischemia modified albumin. 241 249 http://rbmb.net/browse.php?a_code=A-10-254-4&slc_lang=en&sid=1 Sushith Sushith 100319475328460017634 100319475328460017634 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India Herijenahalli Nagaraju Krishnamurthy 100319475328460017635 100319475328460017635 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India Shridhar Reshma 100319475328460017636 100319475328460017636 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India D'Sa Janice 100319475328460017637 100319475328460017637 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India Gopal Madan 100319475328460017638 100319475328460017638 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India Kumar Jeppu Ashok 100319475328460017639 100319475328460017639 No Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India & International Medical School, Management and Science University, Shah Alam, Selangor 40100, Malaysia Mangalore Balakrishna Prathima E-mail: mbprathima@gmail.com 100319475328460017640 100319475328460017640 Yes Department of Biochemistry, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India Bhuvanesh Sukhlal Kalal bhuvanesh611@gmail.com 100319475328460017641 100319475328460017641 No A. J. Research Centre, A. J. Institute of Medical Sciences and Research Centre, Mangaluru 575004, Karnataka, India & Ophthalmology, Visual & Anatomical Sciences, Wayne State University, Kresge Eye Institute, Detroit, Michigan 48201, United States of America.