Reports of Biochemistry and Molecular Biology
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Basic Sciences
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1
admin
2322-3480
2322-3480
10.61186/rbmb
en
jalali
1399
3
1
gregorian
2020
6
1
9
2
online
1
fulltext
en
Evaluation of Adipokines Concentration in Iraqi Patients with Major and Minor Beta Thalassemia
بیوشیمی
Biochemistry
گزارش مورد
Case Report
<div style="text-align: justify;"><strong><em>Background:</em></strong> Beta thalassemia (b-thalassemia) is a type of inherited blood disorder characterized by the impaired production of beta globin chains. b-Thalassemia can be categorized into three subtypes according to symptom severity: b-thalassemia minor, b-thalassemia intermedia, and b-thalassemia major. Adipose tissue functions as an endocrine gland by synthesizing and secreting an array of bioactive peptides including leptin, adiponectin, and resistin.</div>
<div style="text-align: justify;"><strong><em>Methods:</em></strong> We recruited 30 participants who were transfusion dependent b-thalassemia patients (major) and 30 participants who were non-transfusion dependent b-thalassemia patients (minor). The control group consisted of 20 healthy individuals. Analysis of the demographic profile, hematological profile, biochemical parameters, and serum adipokine concentrations (leptin, adiponectin and resistin) were performed for all participants.<br>
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<div style="text-align: justify;"><strong><em>Results:</em></strong> Our results showed that leptin serum levels were significantly lower in the b-thalassemia major group compared with the b-thalassemia minor group or healthy individuals, while serum levels of adiponectin were significantly higher in b-thalassemic patients compared with healthy controls. Serum levels of resistin were significantly higher in b-thalassemic patients compared with the healthy control group. A significant negative correlation was noted between adiponectin and BMI in b-thalassemic patients, whereas leptin was observed to have a significant positive correlation with BMI in the control group. Leptin was observed to have a significant negative correlation with adiponectin and ferritin in the b-thalassemia major group.<br>
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<strong><em>Conclusion:</em> </strong>The changes we observed in adipokine levels may play a role in the development of the complications related to b-Thalassemia and disease severity.
Adipokines, Adiponectin, Beta thalassemia, Leptin, Resistin
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215
http://rbmb.net/browse.php?a_code=A-10-476-1&slc_lang=en&sid=1
Nazar
Sattar Harbi
nazarsattar7890@gmail.com
10031947532846007364
10031947532846007364
Yes
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad.
Alaa
Hussein Jawad
10031947532846007365
10031947532846007365
No
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad.
Farah
Kadhum Alsalman
10031947532846007366
10031947532846007366
No
Retired Doctor from the Iraqi ministry of health, Baghdad