die(' Site is under construction

Dear site users

Site is under construction.

The site will be ready in less than 24 hours.

We are sorry for the inconvenience.

www.yektaweb.com

'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1393 7 1 gregorian 2014 10 1 3 1 online 1 fulltext
en Amelioration of Altered Serum, Liver, and Kidney Antioxidant Enzymes Activities by Sodium Selenite in Alloxan-Induced Diabetic Rats بیوشیمی Biochemistry <p style="text-align: justify;"><em><strong>Background:</strong></em> The aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats.</p> <p style="text-align: justify;"><em><strong>Methods:</strong></em> Forty Sprague-Dawley male rats were randomly divided into four groups; Group one as control, Group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections daily, Group three as diabetic untreated, and Group four as diabetic treated with sodium selenite by 1 mg/kg i.p. injections daily .Diabetes was induced in the third and fourth groups by subcutaneous alloxan injections. After eight weeks the animals were euthanized and livers and kidneys were immediately removed and used fresh or kept frozen until analysis. Before the rats were killed blood samples were also collected to measure glutathione peroxidase (GPX) and catalase (CAT) activities in sera.</p> <p style="text-align: justify;"><em><strong>Results:</strong></em> Glutathione peroxidase and CAT activities serum, liver, and kidney were all significantly less in the diabetic rats than in the controls. Sodium selenite treatment of the diabetic rats resulted in significant increases in GPX activity in the kidneys and livers, and CAT activity in the sera and livers.</p> <p style="text-align: justify;"><em><strong>Conclusions:</strong></em> Our results indicate that sodium selenite might be a potent antioxidant that exerts beneficial effects on both GPX and CAT activities in alloxan-induced type 1 diabetic rats.</p> Antioxidant enzymes activity, Diabetes, Rat, Sodium selenite 14 19 http://rbmb.net/browse.php?a_code=A-10-1-32&slc_lang=en&sid=1 Hassan Ahmadvand hassan_a46@yahoo.com 10031947532846006019 10031947532846006019 Yes Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorram Abad, Iran - Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran Maryam Ghasemi Dehnoo 10031947532846006020 10031947532846006020 No Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran Roohangiz Cheraghi 10031947532846006021 10031947532846006021 No Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran Bahram Rasoulian 10031947532846006022 10031947532846006022 No Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorram Abad, Iran Behrouzb Ezatpour 10031947532846006023 10031947532846006023 No Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorram Abad, Iran Mozhgan Azadpour 10031947532846006024 10031947532846006024 No Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorram Abad, Iran Kaveh Baharvand 10031947532846006025 10031947532846006025 No School of Dental Medicine, Boston University, Boston MA, USA.