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en Association of vitamin D receptor polymorphisms (Fok1 (rs2228570), ApaI (rs7975232), BsmI (rs1544410), and TaqI (rs731236)) with gastric cancer among Kurdish population from west of Iran زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article Background: The association of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) and its receptor, vitamin D receptor (VDR), with cancer types have been studied. However, there are controversial findings regarding the association of specific VDR polymorphisms with different kinds of cancers. In the current study, we investigated the association of VDR polymorphisms (Fok1 (rs2228570), ApaI (rs7975232), BsmI (rs1544410), and TaqI (rs731236)) with the risk of gastric cancer in a Kurdish population of Kermanshah in Iran for the first time. Methods: In this case-control study, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used in 99 gastric cancer patients and 100 healthy subjects as controls. Results: The frequencies of f (FokI), b (BsmI), t (TaqI), and a (ApaI) alleles were: 55.6%, 27.3%, 62.1%, and 44.95% in the patient group, respectively and 42%, 29.5%, 54.5%, and 46.0% in the control group, respectively. Analysis of the results indicated that there was a positive association between the frequency of FokI genotypes with gastric cancer risk (p= 0.021). However, no statistically significant association of BsmI, Taq1, and ApaI polymorphisms of VDR was detected in gastric patients when compared with healthy individuals. Conclusions: VDR-FokI polymorphism could increase the risk of GC development and predispose to the disease by mechanisms. Gastric cancer, PCR-RFLP, Polymorphism, Vitamin D receptor. 435 441 http://rbmb.net/browse.php?a_code=A-10-418-2&slc_lang=en&sid=1 Zohreh Hoseinkhani Zohreh Hoseinkhani z_hoseinkhani_64@yahoo.com 100319475328460017753 100319475328460017753 No Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Mohsen Rastegari-Pouyani Mohsen Rastegari-Pouyani mohsen_hit68@yahoo.com 100319475328460017754 100319475328460017754 No Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Farahnaz Tajemiri Farahnaz Tajemiri f.tajemiri@gmail.com 100319475328460017755 100319475328460017755 No Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kheirollah Yari Yari Kheirollah kyari@kums.ac.ir 100319475328460017756 100319475328460017756 No Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. Kamran Mansouri Mansouri Kamran kamranmansouri@gmail.com 100319475328460017757 100319475328460017757 Yes Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.