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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1400 8 1 gregorian 2021 11 1 10 3 online 1 fulltext
en Analysis of Micro-RNA-144 Expression Profile in Patients with Multiple Sclerosis in Comparison with Healthy Individuals زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Etiology of multiple sclerosis is non-clarified. It seems that environmental factors impact&nbsp;epigenetic in this disease. Micro-RNAs (MIR) as epigenetic factors are one of the most important factors in&nbsp;non-genetically neurodegenerative diseases. It has been found MIR-144 plays a main role in the regulation&nbsp;of many processes in the central nervous system. Here, we aimed to investigation of MIR-144 expression&nbsp;alteration in Multiple sclerosis (MS) patients.&nbsp;<br> <br> <em><strong>Methods: </strong></em>In this study 32 healthy and 32 MS patient&#39;s blood sample were analyzed by quantitative&nbsp;Real-Time PCR method and obtained data analyzed by REST 2009 software.&nbsp;<br> <br> <strong><em>Results:</em></strong> Analysis of Real-Time PCR data revealed that miR-144 Increase significantly in MS patients&nbsp;compared to healthy controls.&nbsp;Conclusions: The increase of MIR-144 expression in MS patients is obvious. MIR-144 can be used&nbsp;as a biomarker of MS and help to early diagnosis and treatment of this disease.<span dir="RTL"></span></div> MicroRNA (miRNA), MiRNA-144, Multiple Sclerosis (MS). 396 401 http://rbmb.net/browse.php?a_code=A-10-520-1&slc_lang=en&sid=1 Fatemeh Roshani 100319475328460012533 100319475328460012533 No Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran. Hossien Delavar Kasmaee 100319475328460012534 100319475328460012534 No medical university of Shahid Beheshti, Tehran, Iran. Kowsar Falahati 100319475328460012535 100319475328460012535 No Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran. Ghazaleh Arabzadeh 100319475328460012536 100319475328460012536 No Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan, Iran. Atefeh Aohan Forooshan Moghadam 100319475328460012537 100319475328460012537 No Department of Genetics, Nourdanesh Institute of higher Education, Myme, Esfahan,Iran. Mohammd Hossein Sanati m-sanati@nigeb.ac.ir. 100319475328460012538 100319475328460012538 Yes Medical Genetic Department, National Institute of Genetics Engineering and Biothechnology, Tehran, Iran.