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en Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and Oxidative Stress in Postmenopausal بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Irisin as an exercise-induced myokine was proposed to improve bone health. This study investigated the role of serum irisin (s-irisin) in patients with osteoporosis (OP) through correlating to most biological bone markers and oxidative stress. Methods: A cross-sectional study recruited an eligible 175 postmenopausal women at Al-Hussien Teaching Hospital, Iraq. They were scanned by DEXA and stratified into two groups based on T-score; the first 95 patients as control group (GI) with −1 ≤ T-score and the second 80 patients as cases group (GII) with T-score ≤ −2.5. Demographic criteria were age, bone mineral density (BMD, g/cm2 ) and T-score. Serum irisin, total serum calcium (s-calcium), serum inorganic phosphate (s-phosphate), serum alkaline phosphatase (s-ALP), serum 25 [OH] vitamin D, the serum parathyroid hormone (s-PTH), serum Carboxy terminal collagen crosslinks (CTx), serum procollagen type I C-termidnal peptide (s-PICP), serum malondialdehyde (s-MDA) and serum superoxide dismutase (s-SOD) were collected from blood samples. Results: Serum irisin were 31.84 ± 2.65 vs. 20.88 ± 2.71 ng/mL for control and trial groups, respectively. Lower levels of BMD, T-score, 25 [OH] vitamin D, and s-irisin along with a higher serum levels of PTH, CTx, PICP, MDA and SOD were observed in patients with osteoporosis. All parameters were statistically meaningful upon correlation (p< 0.0001), except age and s-calcium (p= 0.0088 and p= 0.187, respectively). Conclusions: The results showed that, a significantly lower serum irisin levels among osteoporosis women, was intimately correlated to most bone turnover markers and it can be considered as encouraging results for clinical application in prediction and treatment of osteoporosis</div> Bone turnover markers, DEXA scan, Irisin, T-score, BMD, osteoporosis, post-menopause. 13 19 http://rbmb.net/browse.php?a_code=A-10-618-1&slc_lang=en&sid=1 Ali Badr Roomi : dr.ali_bader@alayen.edu.iq. 100319475328460012710 100319475328460012710 Yes PhD, Ministry of Education, Directorate of Education Thi-Qar, Thi-Qar-64001, Iraq & College of Health and Medical Technology, Al-Ayen University, Thi-Qar-64001, Iraq. Wassan Nori 100319475328460012711 100319475328460012711 No Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Iraq. Roaa Mokram Hamed 100319475328460012712 100319475328460012712 No The National Center of Hematology, Mustansiriyah University, Iraq