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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1394
2
1
gregorian
2015
5
1
3
2
online
1
fulltext
en
Protective Effects of Withania somnifera Root on Inflammatory Markers and Insulin Resistance in Fructose-Fed Rats
زیست شناسی سلولی
Cell Biology
<p><em><strong>Background:</strong></em> We investigated the effects of<em> Withania somnifera</em> root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats.</p>
<p><em><strong>Methods:</strong></em> Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-α levels in sera.</p>
<p><strong><em>Results:</em></strong> Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-α.</p>
<p><em><strong>Conclusion:</strong></em> Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.</p>
IL-6, Insulin resistance, TNF- α, Withania somnifera
62
67
http://rbmb.net/browse.php?a_code=A-10-1-39&slc_lang=en&sid=1
Zahra
Samadi Noshahr
10031947532846006056
10031947532846006056
No
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran
Mohammad Reza
Shahraki
10031947532846006057
10031947532846006057
No
Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran
Hassan
Ahmadvand
hassan_a46@yahoo.com
10031947532846006058
10031947532846006058
Yes
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorram Abad, Iran
Davood
Nourabadi
10031947532846006059
10031947532846006059
No
Department of Physiology, Iran University of Medical Sciences, Tehran, Iran
Alireza
Nakhaei
10031947532846006060
10031947532846006060
No
Department of Pharmacology, Zahedan University of Medical Sciences, Zahedan, Iran