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en Evaluation the Effect of Supplements Containing Vitamin D and Trace Elements in Patients with Moderate to Severe Asthma ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: Asthma is a common and major allergic disease in the world. We aimed to investigate the impact of supplements with vitamin D, folic acid, selenium, zinc, and copper in patients with moderate to severe asthma. Method: In this clinical trial study 70 patients above six years old with moderate to severe asthma, were divided into two groups, randomly; one group received daily Asmavit syrup, 10 ml (Asmavit, Vitabiotics Ltd, London, UK), and the other group received daily 1000 IU vitamin D3 drops (Asmavit, Vitabiotics Ltd, London, UK) for two months along with ordinary treatment for asthma. Clinical and physical examinations, immunological and biochemical tests were carried out for each patient before and after the treatment. Results: The mean age of patients was 39.9± 14.7 years old, and the mean disease duration was 8.8 ± 9.8 years. A significant increase in lung function, asthma control, and quality of life score tests was observed in both groups after the treatment (P< 0.05). There was no significant difference in cytokines expression levels before and after the treatment with vitamin D3 or Asmavit (P> 0.05). Serum levels of selenium and folic acid before treatment were correlated with disease severity, while post-treatment vitamin D levels significantly increased FEV1 (P> 0.05). Oxidative stress levels reduced in both groups, with greater reduction in the vitamin D group (P< 0.05). Conclusion: Supplements, particularly vitamin D, when combined with standard asthma treatment, may effectively improve clinical symptoms and enhance the quality of life for asthmatic patients.</div> Asthma, Vitamin D, Supplements, Oxidative stress. 40 50 http://rbmb.net/browse.php?a_code=A-10-117-1&slc_lang=en&sid=1 Mansoor Ahoon 100319475328460020286 100319475328460020286 No Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Reza Farid-Hosseini 100319475328460020287 100319475328460020287 No Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Hooman Tehrani 100319475328460020288 100319475328460020288 No Department of Pediatrics, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. Houshang Rafat-Panah 100319475328460020289 100319475328460020289 No Immunology Research Center, Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Hamid Ahanchian 100319475328460020290 100319475328460020290 No Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Hadis Yousefzadeh 100319475328460020291 100319475328460020291 No Immunology Research Center, Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Seyed Abdolrahim Rezaee 100319475328460020292 100319475328460020292 No Immunology Research Center, Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Maral Barzegar-Amini 100319475328460020293 100319475328460020293 No Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Farahzad Jabbari-Azad jabbarif@mums.ac.ir 100319475328460020294 100319475328460020294 Yes Allergy research Center, Mashhad University of Medical Sciences, Mashhad, Iran.