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en Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><strong><em>Background:</em></strong> Chronic hepatitis B is a necro-inflammatory of the liver parenchyma caused by hepatitis B virus (HBV) infection leading to liver cirrhosis and hepatocellular carcinoma (HCC). Genetic variants including single nucleotide polymorphisms (SNPs) within genes regulating immune response may contribute to the progression of chronic hepatitis B (CHB) infection. This study aimed to examine the genotype distribution of vitamin D receptor (VDR) polymorphism among patients with CHB infection and to study its association with the development of cirrhosis and hepatoma.<br>  </div> <div style="text-align: justify;"><strong><em>Methods:</em></strong> This cross-sectional study analysed 75 CHB patients, consisting of 36 CHB patients without cirrhosis, 25 CHB patients with cirrhosis, and 14 CHB patients with hepatoma. VDR polymorphism was examined using the Amplification Refractory Mutation System Polymerase Chain Reaction (ARMS-PCR) method.</div>   <div style="text-align: justify;"><strong><em>Results:</em></strong> Alanine aminotransferase (ALT) and alpha fetoprotein (AFP) levels did not show any significant differences between study groups, but albumin levels in CHB patients with cirrhosis and hepatoma were significantly lower than CHB patients without cirrhosis (<em>p</em>< 0.05). In contrast, the bilirubin levels in CHB patients with cirrhosis was higher than in CHB patients’ cirrhosis. The most common genotypes of VDR polymorphisms were Ff (57.3%), TT (72%), aa (48%) and bb (74.7%) for Fok1, Taq1, Apa1 and Bsm1 respectively. There was no significant different in the genotype distribution of VDR polymorphism between CHB patients without cirrhosis and CHB with cirrhosis or hepatoma.</div> <br> <strong><em>Conclusions:</em></strong> This study suggest that VDR gene polymorphism may not contribute to the progression of CHB infection. Cirrhosis, Hepatitis B, Hepatoma, Polymorphism, Vitamin D Receptor. 463 469 http://rbmb.net/browse.php?a_code=A-10-626-1&slc_lang=en&sid=1 Arfianti Arfianti Arfianti@unri.ac.id 100319475328460017764 100319475328460017764 Yes Department of Medical Biology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia. Athalah Sabillah Sumpena 100319475328460017765 100319475328460017765 No Undergraduate of Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia. Fauzia Andrini Djojosugito 100319475328460017766 100319475328460017766 No Department of Microbiology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia. Dita Kartika Sari 100319475328460017767 100319475328460017767 No Department of Anatomy, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia. Ariza Julia Paulina 100319475328460017768 100319475328460017768 No Department of Clinical Pathology, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia.