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en Pre Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34 + Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation بیوشیمی Biochemistry مقالات اصلی Original Article Background: Parathyroid hormone (PTH) is a calcium homeostasis regulator and can affect bone marrow niche. PTH leads to the bone marrow stem cell niche expansion as well as the induction of stem cell mobilization from the bone marrow into peripheral blood. In this study, we evaluated the association between pre- transplantation serum PTH levels and the number of circulating CD34+ cells along with the platelets/white blood cells (Plt/WBC) engraftment in patients who underwent autologous Hematopoietic Stem Cell Transplantation . Methods: Subjects for the study were 100 patients who received autologous hematopoietic stem cell transplantation (auto-HSCT), retrospectively. Serum levels of PTH, calcium, phosphorus, and alkaline phosphatase were measured before mobilization. Their impacts were measured on the number of mobilized CD34+ hematopoietic stem cells, and Plt/WBC engraftment. Results: High levels of serum PTH (> 63.10 pg/mL) was significantly associated with higher number of CD34+ cells in peripheral blood after granulocyte- colony stimulating factor (G-CSF)-induced mobilization (p= 0.079*). Serum calcium at low levels were associated with higher number of circulating CD34+ cells post mobilization. Pre- transplantation serum levels of phosphorus and alkaline phosphatase on CD34+ numbers were not statistically significant. Serum Plt/WBC engraftment was not improved in presence of high levels of serum PTH. Conclusions: We suggested that serum PTH levels before transplantation could be influential in raising the number of circulating CD34+ hematopoietic stem cell after mobilization. Auto-HSCT, CD34+ Cell, Pre- transplant PTH. 76 83 http://rbmb.net/browse.php?a_code=A-10-633-1&slc_lang=en&sid=1 Abdolhamed Kian 100319475328460012741 100319475328460012741 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Sayeh Parkhideh s.parkhideh@sbmu.ac.ir. 100319475328460012742 100319475328460012742 Yes Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Haniyeh Ghaffari Nazari 100319475328460012743 100319475328460012743 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Maryam Nikoonezhad 100319475328460012744 100319475328460012744 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Arsalan Jalili 100319475328460012745 100319475328460012745 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shaghayegh Shahsavan 100319475328460012746 100319475328460012746 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Abbas Hajifathali 100319475328460012747 100319475328460012747 No Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.