Reports of Biochemistry and Molecular Biology
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2021
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Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after
Kidney Transplantation
ایمنی شناسی
Immunology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> Cytomegalovirus (CMV) infection is the most common complications following kidney transplantation. Natural killer (NK) cells demonstrated critical anti-viral role in controlling and elimination of CMV after transplantation. Interleukin-15 (IL-15) is a pleiotropic cytokine that promotes the activity of NK cells and strengthens the acquired immune system. Also, IP10 (CXCL10) is a chemotactic factor which regulates NK cell recruitment and antiviral immune response. We aimed to determine the correlation between the serum levels of IL-15 and IP-10 cytokines with CMV infection, CMV viral load, and cyclosporine as a major immunosuppressive treatment after transplantation.<br>
<br>
<strong><em>Methods:</em></strong> Fifty-eight kidney transplant recipient patients without evidence of CMV virus disease before transplantation surgery were included in the study. From the day of transplant surgery, the patients were evaluated based on the presence of CMV Ag pp65, CMV viral load, serum levels of IL-15 & IP-10, Cyclosporine levels (C0 & C2), Glomerular Filtration Rate (GFR), and hematological & biochemical Index, up to 75 days.<br>
<br>
<strong><em>Results:</em></strong> Comparison analysis of serum levels of IL-15 and IP-10 showed no significant association with CMV infection in kidney transplant recipients. In addition, CMV viral load and cyclosporine levels at C0 and C2 did not affect patients' IL-15 and IP-10 levels.<br>
<br>
<strong><em>Conclusions:</em></strong> The levels of IP-10 and IL-15 cytokines are not affected with CMV infection, even if a viral infection occurs in the early days after transplantation or long afterwards. In addition, taking the different levels of cyclosporine did not affect the cytokines levels. Other mechanisms may play a role in maintaining the levels of these cytokines.</div>
Cytokine, Cytomegalovirus, IP-10, Interleukin-15, Transplantation.
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223
http://rbmb.net/browse.php?a_code=A-10-529-2&slc_lang=en&sid=1
Reza
Asadzadeh
100319475328460012621
100319475328460012621
No
Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pedram
Ahmadpoor
pedram.ahmadpoor@gmail.com
100319475328460012622
100319475328460012622
Yes
Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohsen
Nafar
100319475328460012623
100319475328460012623
No
Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shima
Samavat
100319475328460012624
100319475328460012624
No
Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hassan
Nikoueinejad
100319475328460012625
100319475328460012625
No
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Morteza
Hosseinzadeh
100319475328460012626
100319475328460012626
No
Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Nahid
Mamizadeh
100319475328460012627
100319475328460012627
No
Department of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Saeideh
Hatami
saeideh.atami@yahoo.com
100319475328460012628
100319475328460012628
No
Department of Tissue Engineering and Regenerative Medicine, Iran university of Medical Sciences, Tehran, Iran.
Elham
Masoumi
100319475328460012629
100319475328460012629
No
Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.
Aliakbar
Amirzargar
100319475328460012630
100319475328460012630
No
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.