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en Association of IL-15 and IP-10 Serum Levels with Cytomegalovirus Infection, CMV Viral Load and Cyclosporine Level after Kidney Transplantation ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: Cytomegalovirus (CMV) infection is the most common complications following kidney transplantation. Natural killer (NK) cells demonstrated critical anti-viral role in controlling and elimination of CMV after transplantation. Interleukin-15 (IL-15) is a pleiotropic cytokine that promotes the activity of NK cells and strengthens the acquired immune system. Also, IP10 (CXCL10) is a chemotactic factor which regulates NK cell recruitment and antiviral immune response. We aimed to determine the correlation between the serum levels of IL-15 and IP-10 cytokines with CMV infection, CMV viral load, and cyclosporine as a major immunosuppressive treatment after transplantation. Methods: Fifty-eight kidney transplant recipient patients without evidence of CMV virus disease before transplantation surgery were included in the study. From the day of transplant surgery, the patients were evaluated based on the presence of CMV Ag pp65, CMV viral load, serum levels of IL-15 & IP-10, Cyclosporine levels (C0 & C2), Glomerular Filtration Rate (GFR), and hematological & biochemical Index, up to 75 days. Results: Comparison analysis of serum levels of IL-15 and IP-10 showed no significant association with CMV infection in kidney transplant recipients. In addition, CMV viral load and cyclosporine levels at C0 and C2 did not affect patients' IL-15 and IP-10 levels. Conclusions: The levels of IP-10 and IL-15 cytokines are not affected with CMV infection, even if a viral infection occurs in the early days after transplantation or long afterwards. In addition, taking the different levels of cyclosporine did not affect the cytokines levels. Other mechanisms may play a role in maintaining the levels of these cytokines.</div> Cytokine, Cytomegalovirus, IP-10, Interleukin-15, Transplantation. 216 223 http://rbmb.net/browse.php?a_code=A-10-529-2&slc_lang=en&sid=1 Reza Asadzadeh 100319475328460012621 100319475328460012621 No Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Pedram Ahmadpoor pedram.ahmadpoor@gmail.com 100319475328460012622 100319475328460012622 Yes Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mohsen Nafar 100319475328460012623 100319475328460012623 No Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shima Samavat 100319475328460012624 100319475328460012624 No Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Hassan Nikoueinejad 100319475328460012625 100319475328460012625 No Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Morteza Hosseinzadeh 100319475328460012626 100319475328460012626 No Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Nahid Mamizadeh 100319475328460012627 100319475328460012627 No Department of Nephrology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Saeideh Hatami saeideh.atami@yahoo.com 100319475328460012628 100319475328460012628 No Department of Tissue Engineering and Regenerative Medicine, Iran university of Medical Sciences, Tehran, Iran. Elham Masoumi 100319475328460012629 100319475328460012629 No Department of Immunology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Aliakbar Amirzargar 100319475328460012630 100319475328460012630 No Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.