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en Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients. Methods: UCP2 gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in 93 participants divided into three groups. The groups included 31 non-obese CKD patients, 31 obese CKD patients, and 31 healthy, age-matched, unrelated volunteers as a control group. Results: UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0.001). No significant association was found when the groups were compared by gender; Chi-square (X2) was 2.38 and p= 0.304. A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0.05). Conclusions: These results indicate that UCP2 gene expression plays a significant role as a risk factor for obesity in CKD patients.</div> Chronic kidney disease (CKD), obesity, Uncoupling protein 2 (UCP2) gene expression, Real-Time polymerase chain reaction (RT-PCR) 119 125 http://rbmb.net/browse.php?a_code=A-10-671-1&slc_lang=en&sid=1 Salma Ahmed Shawky 100319475328460012777 100319475328460012777 No Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Osama Gaber 100319475328460012778 100319475328460012778 No Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Ezzat Mostafa 100319475328460012779 100319475328460012779 No Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Walaa Mohamed Sarhan 100319475328460012780 100319475328460012780 Yes Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.