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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1394 2 1 gregorian 2015 5 1 3 2 online 1 fulltext
en Pattern of Infection and Antibiotic Activity among Streptococcus agalactiae Isolates from Adults in Mashhad, Iran میکروب شناسی Microbiology <p><em><strong>Background:</strong></em> One of the main causes of sexually transmitted diseases is group <em>B &beta;- hemolytic streptococci</em> (GBS) multiplying in the genital tracts. Penicillin is the most common drug for the treatment of infections caused by these bacteria, but in patients suffering from Penicillin allergy, Erythromycin and Clindamycin are used as alternative therapeutic drugs against GBS. Recently, resistance to these drugs has been reported more often. In this study, efforts have been made to determine the prevalence and antibiotic resistance of GBS.</p> <p><strong><em>Methods:</em></strong> Modified Christie Atkins Munch-Petersen (CAMP) test was conducted on over 2400 samples of urine and discharge taken from vagina, urethra and prostate. The drug sensitivity was performed by double disk sensitivity tests to Bacitracin, Trimethoprim, and Sulfamethoxazole and then the resistant samples were investigated by E-test to determine the minimal inhibitory concentrations (MICs) value.</p> <p><em><strong>Results: </strong></em>Twenty-three vaginal and 10 urethral discharge, 27urine and 6 prostatic secretion samples were GBS positive. The most symbiotic microorganisms with GBS were strains of <em>Enterococci</em> (90%), <em>Staphylococcus saprophyticus</em> (25%) and <em>Candida albicans</em> (6%). The disk diffusion method showed 18 cases with Penicillin resistance (MIC: 1.5 mg/ml).</p> <p><em><strong>Conclusion: </strong></em>Taken together, GBS carriers&rsquo; rate in this study was found 20.65% (8.24% men and 12.4% women). Furthermore, findings showed high-level resistance to Erythromycin and Clindamycin.</p> Antibiotic resistance, Genitourinary system, Minimal inhibitory concentration (MIC), Streptococcus agalactiae, 89 93 http://rbmb.net/browse.php?a_code=A-10-1-43&slc_lang=en&sid=1 Masoumeh Malek-Jafarian 10031947532846006074 10031947532846006074 No Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh-Sadat Hosseini Hosseinif68@yahoo.com 10031947532846006075 10031947532846006075 Yes Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran Abodol-Reza Ahmadi 10031947532846006076 10031947532846006076 No Department of Laboratory Medicine, School of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran