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en Highlighting Levels of Indoxyl Sulphate among Critically Ill Patients with Acute Nephrotoxicity; Correlations Between Indoxyl Sulphate Levels and Patients’ Characteristics بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Many animal studies suggested that the uremic toxin indoxyl sulphate can add to renal damage following induced nephrotoxicity and this effect has not been proved in patients with such complication. Methods: This is a prospective, case-control, and an observational study conducted on 74 critically ill patients with acute nephrotoxicity. It was designed to measure serum levels of indoxyl sulphate on the day of enrollment and over the course of their illness using high performance liquid chromatography (HPLC-UV) and to test the correlation between these levels and patient’s demographics, clinical characteristics, physiological variables, and their outcomes. Results: Critically ill patients with acute nephrotoxicity had significantly higher total (tIS) and free (fIS) indoxyl sulphate than healthy controls and significantly lower than patients with end-stage renal disease (ESRD). Although, no correlation was found between tIS or fIS and mortality, among survivors, tIS, fIS, creatinine and eGFR were independently associated with no renal recovery. Conclusions: Serum indoxyl sulphate levels were elevated in critically ill patients with acute nephrotoxicity. There is an association between high levels of indoxyl sulphate and no renal-recovery outcome among survivors of acute nephrotoxicity. Early removal of indoxyl sulphate from patients’ blood may improve their outcomes.</div> HPLC, Indoxyl sulphate, Mortality, Prognosis, Toxic acute kidney injury. 266 279 http://rbmb.net/browse.php?a_code=A-10-673-1&slc_lang=en&sid=1 Nermien Yousef Selim 100319475328460015478 100319475328460015478 No Medical Research Center, Faculty of Medicine, University of Alexandria, Egypt. Hazem Farag Mannaa amir.monfaredan@yahoo.com 100319475328460015479 100319475328460015479 Yes Medical Biochemistry Department, Faculty of Medicine, University of Alexandria, Egypt. Ola Atef Sharaki 100319475328460015480 100319475328460015480 No Clinical Pathology Department, Faculty of Medicine, University of Alexandria, Egypt. Tayseer Zaytoun 100319475328460015481 100319475328460015481 No Critical Care Medicine center, Faculty of Medicine, University of Alexandria, Egypt. Noha Elkholy 100319475328460015482 100319475328460015482 No Nephrology Department, Faculty of Medicine, University of Alexandria, Egypt. Waleed Arafat 100319475328460015483 100319475328460015483 No Clinical Oncology Department, Faculty of Medicine, University of Alexandria, Egypt.