Site is under construction

en Association of Serum Asymmetric Dimethylarginine with the Severity of Coronary Artery Disease: A Pilot Study بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Asymmetric dimethylarginine (ADMA), an inhibitor of nitric oxide synthase (NOS), has been implicated in endothelial dysfunction and atherogenesis. Though there is much evidence linking ADMA with atherosclerosis and adverse cardiovascular events, only a few studies have established the independent relationship between elevated ADMA and the angiographic extent of coronary artery disease (CAD). The aim of the study was to analyze serum ADMA levels in patients with varied extent and severity of coronary atherosclerosis and to see whether the levels of ADMA in male and female participants vary significantly. Methods: We analyzed 40 individuals with obstructive CAD, including men and women, between the ages of 30 and 60. According to their coronary angiographic reports, the participants were divided into four groups: minor CAD, single vessel disease (SVD), double vessel disease (DVD) group and triple vessel disease (TVD). Then, serum ADMA levels was measured and compared among these groups. Results: ADMA level was significantly higher in patients with TVD (167.74±16.69) than those in the DVD (159.46±10.40), SVD (149.54±16.39) and minor CAD (144.5± 24.16) group (p-value= 0.0001). There was no significant difference in ADMA levels between male and female participants (p= 0.534). Conclusions: ADMA concentration in the serum may be useful in identifying whether CAD correlates significantly to the extent and severity of coronary atherosclerosis.</div> ADMA, CAD, Endothelial dysfunction, NOS, Atherosclerosis. 302 306 http://rbmb.net/browse.php?a_code=A-10-681-1&slc_lang=en&sid=1 Lakshmi Goudhaman 100319475328460012673 100319475328460012673 No Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Poonamallee, Chennai-600123, India. Anusha Raja Jagadeesan lakshmigoudhaman@gmail.com 100319475328460012674 100319475328460012674 No Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Poonamallee, Chennai-600123, India. Saranya Sundaramoorthi 100319475328460012675 100319475328460012675 No Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Poonamallee, Chennai-600123, India. Spandana Thotla spandanathotla10@gmail.com. 100319475328460012676 100319475328460012676 Yes Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Poonamallee, Chennai-600123, India. Surapaneni Krishna Mohan 100319475328460012677 100319475328460012677 No Department of Biochemistry, Panimalar Medical College Hospital & Research Institute, Poonamallee, Chennai-600123, India.