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en Expression of Vascular Endothelial Growth Factor A and Its Type 1 Receptor in Supratentorial Neoplasm ایمنی شناسی Immunology مقالات اصلی Original Article Background: Vascular endothelial growth factor (VEGF) is one of the main angiogenesis regulators in solid cancers. The brain solid tumors are life threatening diseases in which angiogenesis is an important phase of development and progression. In the present study the gene expression of VEGF-A and VEGF receptor (VEGF-R1) were evaluated in CNS brain tumors. Methods: The quantification of the VEGF-A and VEGF-R1 expressions was carried out by real-time PCR on fresh biopsies of 38 supratentorial brain tumors compared to 30 non-tumoral tissues. Then the correlations were investigated with clinic-pathological and demographic factors of the patients. Results: PCR products sequencing confirmed the validity of the qRT-PCR. Although, VEGF-A and VEGF-R1 expression showed increased trends with progression of cell proliferation in different stages of astrocytoma (p=0.006,p=0.07, respectively), in case of VEGF-R1 did not met 95% confidence interval in other brain tumors. An increasing trend in VEGF-A and a declining trend in VEGF-R1 expression from stage-I to II were observed in meningioma.VEGF-A and VEGF-R1 expressions had not significant correlation with age and gender. Although, peritumoral brain edema (PTBE) in astrocytoma was significantly associated with tumor stages (p=0.01), VEGF-A and VEGF-R1 had not associations with PTBE in meningioma and metastasis. Conclusion: VEGF-A is a valuable factor for prognosis of PTBE and malignancy stage in astrocytoma, and useful for monitoring of the treatment approaches. Angiogenesis, Brain edema, Brain neoplasm, Peritumoral brain, VEGF, VEGFR1. 354 361 http://rbmb.net/browse.php?a_code=A-10-736-1&slc_lang=en&sid=1 Hamid Rezaee 100319475328460012510 100319475328460012510 No Neurosurgery Department, Mashhad University of Medical Sciences, Mashhad, Iran. Shadi Abbasnia 100319475328460012511 100319475328460012511 No Immunology Research Centre, Inflammation and inflammatory Diseases division, Mashhad University of Medical Sciences, Mashhad, Iran. Anita Alenabi 100319475328460012512 100319475328460012512 No Shariati Hospital, Department of Pathology, Mashhad University of Medical Sciences, Mashhad, Iran. Rosita Vakili 100319475328460012513 100319475328460012513 No Immunology Research Centre, Inflammation and inflammatory Diseases division, Mashhad University of Medical Sciences, Mashhad, Iran. Nasrin Moheghi 100319475328460012514 100319475328460012514 No Genetic Laboratory, Qaem Hosp. Mashhad University of Medical Sciences, Mashhad, Iran. Jalil Tavakol Afshari 100319475328460012515 100319475328460012515 No Immunology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran. Seyed Abdolrahim Rezaee rezaeer@mums.ac.ir. 100319475328460012516 100319475328460012516 Yes Immunology Research Centre, Inflammation and inflammatory Diseases division, Mashhad University of Medical Sciences, Mashhad, Iran.