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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1400
8
1
gregorian
2021
11
1
10
3
online
1
fulltext
en
Effects of Andrographis paniculata (Burm. F.)
Extract on Diabetic Nephropathy in Rats
زیست شناسی ملکولی
Molecular Biology
مقالات اصلی
Original Article
<div style="text-align: justify;"><strong><em>Background:</em></strong> Hyperglycemia and accumulation of advanced glycation end products (AGEs) play a significant role in the development of diabetic nephropathy. Andrographis paniculata (AP) is a plant with high flavonoid content with the potential to suppress oxidative stress activity in cells and tissue. This study was aimed to investigate the role of Andrographis paniculata extract (APE) in protecting kidney damage due to the formation of AGEs in the renal glomerulus in diabetic rats.<br>
<br>
<em><strong>Methods:</strong></em> A total of 30 male Sprague Dawley rats were randomly divided into five groups as follows: normal control group, streptozocin (STZ) induced diabetic group, STZ-induced diabetic group with AP extract (100 mg/kg BW), STZ-induced diabetic rats with AP extract (200 mg/kg BW), and STZinduced<br>
diabetic rats with APE (400 mg/ kg BW). Blood glucose levels were measured before treatment and after treatment. Serum and urine parameters were determined. Antioxidant enzymes and lipid peroxide levels were determined in the kidney along with histopathological examination.<br>
<br>
<strong><em>Results:</em></strong> The finding of this study showed that treatment APE at the dose of 200 mg/kg and 400 mg/kg ameliorated kidney hypertrophy index. SOD, catalase, and GSH activities significantly decreased in the kidney of STZ-diabetic rats compared to the normal control rats. Treatment with APE<br>
significantly decreased malondialdehyde level at the dose of 200 and 400 mg/kg BW.<br>
<br>
<em><strong>Conclusions:</strong></em> This study revealed evidence for improving diabetic retinopathy in male rats treated with Andrographis paniculata extract. APE significantly decreased oxidative stress activities in kidney of diabetic rats.</div>
Andrographis, Diabetic Nephropathies, Streptozocin, Rats, Oxidative Stress.
445
454
http://rbmb.net/browse.php?a_code=A-10-747-1&slc_lang=en&sid=1
Rachmat
Hidayat
dr.rachmat.hidayat@gmail.com.
100319475328460012554
100319475328460012554
Yes
Department of Biology, Faculty of Medicine, Universitas Sriwijaya.
Patricia
Wulandari
100319475328460012555
100319475328460012555
No
Department of Biological Psychiatry, Cattleya Mental Health Center, Jl Sirnaraga No 99 Kel 8 Ilir, Palembang, 30662, Indonesia.