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en The Cytokines Responses against Parvovirus B19 in Miscarriage Women and the Susceptibility of their RhD Blood Type to Contract Parvovirus B19 in South of Iraq زیست شناسی سلولی Cell Biology مقالات اصلی Original Article Background: Parvovirus B19 (B19) infection is linked with various diseases. Cytokines play critical roles in cellular response to viral infection. It has also been reported that’s susceptibility of the ABO blood type people to several viral infection. In this study, we evaluated interleukin 6 (IL-6), interleukin 8(IL-8), and interferon gamma (IFN-γ) levels in aborted women infected with parvovirus B19 (B19+/Abr+) and uninfected with B19(B19-/Abr+) in comparison with healthy women (B12-/Abr-) and susceptibility of their RhD blood type to contract B19. Methods: B19+/Abr+ were diagnosed using IgM and IgG antibodies against B19, and the concentrations of IL-6, IL-8, and IFN-γ were determined using enzyme-linked immunosorbent assay (ELISA) test in both B19+/Abr+, B19-/Abr+, and B19-/Abr-. Here, we also collected blood groups, number of abortion, and gestational ages from 200 B19+/Abr+ along with the same number ofB19-/Abr+ and B19-/Abr-. Results: The levels of IFN-γ were higher in serum of B19-/Abr+andB19+/Abr+ group in comparison to B19-/Abr-, while the serum levels of IL-6, IL-8were increased in B19+/Abr+ group in comparisontoB19-/Abr+ and B19-/Abr-. Our analyzed data also showed that aborted women with RhD+ are more susceptible to contract s B19 than people with RhD- blood type. Conclusions: B19 infection may differently modulate the amount of cytokines in the plasma of aborted women. So, it can be suggested that IL-6, IL-8, and IFN-γ potentially useful as markers for inflammation intrauterine. The susceptibility/protection of aborted women against B19 might be determined based on RhD blood type. Aborted women, IL-6, IL-8, IFN-γ, Parvovirus B19, RhD blood type. 462 470 http://rbmb.net/browse.php?a_code=A-10-749-2&slc_lang=en&sid=1 Dhurgham Al-Fahad dhurgham.alfahad@sci.utq.edu.iq. 100319475328460012562 100319475328460012562 Yes Department of Pathological Analysis, College of Science, University of Thi-Qar,Thi-Qar, Iraq. Khalid Majeed 100319475328460012563 100319475328460012563 No Iraq. 2: Department of Medical Laboratory Technique, Al-Nasiriyah Technical Institute, Southern Technical University, Thi-Qar, Iraq. Ahmed Al-Naqshbandi 100319475328460012564 100319475328460012564 No Department of Laboratory, Rizgary Teaching Hospital, Erbil, Kurdistan Region, F.R. Iraq. Ahmed Al-Amery 100319475328460012565 100319475328460012565 No Department of Physiology, College of Medicine, University of Thi-Qar, Thi-Qar, Iraq. Bandar Fahad Alharbi 100319475328460012566 100319475328460012566 No Department of clinical laboratory, College of Applied Medical Science, University of Hail, Hail, Saudia Arabia.