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en Lectin-Like OLR1 3′UTR Rs1050286 Gene Polymorphism and Plasma Oxidized-LDL in Coronary Artery Disease and Their Relation to Cardiovascular Risk and Outcomes زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div></div> <h3 style="text-align: justify;"><strong><em> Background:</em></strong> Oxidized low-density lipoprotein (ox-LDL) has an important role in the genesis of coronary atherosclerosis. Lectin-like ox-LDL receptor 1 (OLR1) contributes to the uptake and internalization of ox- LDL. Genetic polymorphisms have been associated with coronary artery disease (CAD). Here we explore the association of plasma levels of ox-LDL and 3′ UTR OLR1 (rs1050286) SNP with CAD risk and inhospital adverse outcomes.</h3> <h3></h3> <h3><em><strong>Methods:</strong></em> A case-control study enrolled 192 patients with ST-segment elevation myocardial infarction (STEMI), 100 patients with unstable angina, and 100 healthy controls. Baseline, clinical characteristics, and risk scores of the patients were determined. Plasma ox-LDL and other biochemical variables were measured. All subjects are genotyped for OLR1 (rs1050286) by RT-PCR with TaqMan SNP genotyping assay.</h3> <h3 style="text-align: justify;"><strong><em>Results:</em></strong> Plasma ox-LDL was higher with enhanced sensitivity and specificity in identifying patients with STEMI and was found as a significant independent risk factor for CAD in those two groups. Levels of ox-LDL were increased with increasing poor prognostic factors in STEMI patients that are associated with an increased incidence of some adverse events and in-hospital mortality. Elevated STEMI risk was associated with T allele of OLR1 (rs1050286) (odds ratio of 4.9, 95% CI: 2.6-9.4, p< 0.001). STEMI patients who have T allele exhibited higher risk scores, coronary multivessel narrowing, and elevated incidence of in-hospital major adverse clinical events.</h3> <h3 style="text-align: justify;"><em><strong>Conclusions:</strong></em> These results suggest that plasma ox-LDL, as well as T allele of ORL-1 (rs1050286), is associated with the increased risk for developing STEMI and the associated adverse clinical outcomes.</h3> Coronary artery disease, genotyping, OLR1, outcomes, Oxidized low-density lipoprotein. 537 553 http://rbmb.net/browse.php?a_code=A-10-839-1&slc_lang=en&sid=1 Hanan Sharaf El-Deen Mohammed 100319475328460012403 100319475328460012403 No Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt. Manal Mohamed Kamal 100319475328460012404 100319475328460012404 No Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt. Hala Mostafa ElBadre 100319475328460012405 100319475328460012405 No Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt. Amal Hosni 100319475328460012406 100319475328460012406 No Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt. Azza Abo Elfadl 100319475328460012407 100319475328460012407 No Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt. Mohamed Ahmed Mostafa 100319475328460012408 100319475328460012408 No Department of Anesthesia, ICU and Pain Relief, South Egypt Cancer Institute, Assiut University, Assiut, Egypt. Reham Ibrahim El-Mahdy reham.elmahdy@aun.edu.eg. 100319475328460012409 100319475328460012409 Yes Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Assiut University, Assiut, Egypt.