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en Relationship Between IL-2, IL-17 Concentrations, and Serum Creatinine Levels in Men with Chronic Kidney Disease بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: Chronic kidney disease (CKD), is a major public health challenge worldwide. It is more prevalent in developed countries compared with the rest of the world, due to the higher rates of life expectancy and unhealthy lifestyle related factors. This aim of the current study is to evaluate the relationship between interleukins IL-2 and IL-17 concentrations and kidney function markers in men with CKD. Methods: Forty-five men with CKD and seventy controls were enrolled in the current study to assess the relationship between interleukin-2 (IL-2), interleukin-17 (IL-17), and CKD parameters. Fasting blood samples were collected from patients with CKD and their controls at same time. Serum IL-2, and IL-17 were measured in patients with CKD and their controls, and then the relationship between these interleukins and serum creatinine, serum urea, serum uric acid and urine albumin were evaluated. Results: A significant relationship was detected between IL-2 (p< 0.001), IL-17 (p< 0.001) levels and serum creatinine concentrations. The significant increase of IL-2 and IL-17 levels were also paralleled with a significant increase in serum urea (p< 0.001), and urine albumin (p< 0.001) concentrations respectively. Conclusions: IL-2 and IL-17 may play a critical role in the pathophysiology of CKD. The significant increase of IL-2 and IL-17 is associated with significantly high concentrations of creatinine, serum urea and urine albumin suggesting that these interleukins may be used as targets for future biomarkers and molecular therapy. However, due to limited sample size of the current study, larger prospective cohorts are needed to confirm these observations.</div> Chronic kidney disease, Interleukins, Serum creatinine, Serum urea, Urine albumin. 664 674 http://rbmb.net/browse.php?a_code=A-10-838-1&slc_lang=en&sid=1 Khalid Farouq Al-rawi 100319475328460012474 100319475328460012474 No Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. Hameed Hussein Ali 100319475328460012475 100319475328460012475 No Department of Chemistry, College of Science, University of Anbar, Al-anbar Province, Iraq. Manaf Abdulrahman Guma 100319475328460012476 100319475328460012476 No Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. Bilal Jasir Mohammed Aldahham 100319475328460012477 100319475328460012477 No Department of Applied Chemistry, College of Applied Sciences, University of Anbar, Al-anbar Province, Iraq. Shakir Faris Tuleab Alaaraji 100319475328460012478 100319475328460012478 No Department of Chemistry, College of Education for pure Science, University of Anbar, Al-anbar Province, Iraq. Osamah Al-ani 100319475328460012479 100319475328460012479 No Yarmouk Academic Hospital, Baghdad, Iraq. Aus Tariq Ali drali@europe.com. 100319475328460012480 100319475328460012480 Yes University of Anbar, Al-anbar Province, Iraq.