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en Serum Myeloperoxidase as a Biomarker of Asthma Severity Among Adults: A Case Control Study ایمنی شناسی Immunology مقالات اصلی Original Article <div style="text-align: justify;">Background: The contribution of neutrophils is still indistinct in the inflammatory response of bronchial asthma (BAs). Myeloperoxidase (MPO) is an  enzyme released from the primary azurophilic granules of the neutrophils. The study aimed to evaluate the levels of serum MPO as a biomarker for the assessment of the level of asthma control.  Methods: The study participants included 94 asthmatic patients and 86 healthy controls. The identification of asthma severity had assessed using the ''Global Initiative for Asthma guidelines''. Asthmatic adults had divided into three groups: Good (n= 22), partial (n= 30), and poor control (n=44). Also, patients have been divided again into two groups (treated and untreated) for BAs. Results: The predicted FEV1% and the peak expiratory flow (PEF/L) of all participants had verified by spirometry. The mean patients’ age was 31.9±15.1 year, with a predominance of females. The mean asthma duration was 10.5±8.6 years. Mean spirometric parameters (FEV1 and PEF) were significantly lower among the patients (0.00). Significant higher MPO levels had observed among BAs patients (p-0.00). The MPO levels have not differed significantly with asthma levels and had significant differences with the history of treatment. There was a nonsignificant negative correlation between the mean MPO levels and the spirometry variables among the patients. ROC curves revealed a sensitivity, specificity, accuracy for MPO (80.9%, 72.1%, and 84.3%), respectively to predict asthmatic severity. Conclusions: There were significantly higher MPO levels compared to healthy controls. Levels of serum MPO had a non-significant positive correlation with levels of asthma control, but a negative non-significant correlation with spirometric results.</div> Asthma, And Neutrophils, FEV1, MPO, PEF. 182 189 http://rbmb.net/browse.php?a_code=A-10-872-2&slc_lang=en&sid=1 Shaymaa Obaid Abdullah 100319475328460012385 100319475328460012385 No Department of biology, College of science for woman, University of Babylon, Iraq. Ghazi Mohamad Ramadan 100319475328460012386 100319475328460012386 No Ahlulbayt University College, Karbala, Iraq. Hayder Abdul-Amir Makki Al-Hindy phar.hayder.abdul@uobabylon.edu.iq. 100319475328460012387 100319475328460012387 Yes College of Pharmacy, University of Babylon, Babylon, Iraq. Mazin Jaafar Mousa 100319475328460012388 100319475328460012388 No College of Pharmacy, University of Babylon, Babylon, Iraq. Amir Al-Mumin 100319475328460012389 100319475328460012389 No Hammurabi Medical College, University of Babylon, Babylon, Iraq. Safa Jihad 100319475328460012390 100319475328460012390 No College of Pharmacy, University of Babylon, Babylon, Iraq. Suhad Hafidh 100319475328460012391 100319475328460012391 No College of Pharmacy, University of Babylon, Babylon, Iraq. Yaqeen Kadhum 100319475328460012392 100319475328460012392 No College of Pharmacy, University of Babylon, Babylon, Iraq.