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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1395 7 1 gregorian 2016 10 1 5 1 online 1 fulltext
en Trace Elements Status in Sera of Patients with Allergic Asthma بیوشیمی Biochemistry <p style="text-align: justify;"><em><strong>Background: </strong></em>Asthma is a multifactorial disease and its severity varies with the inflammatory grade. There are conflicting reports about the roles of trace elements in asthma. This study examined the effects of zinc (Zn), copper (Cu), and selenium (Se) concentrations in sera of patients with allergic asthma attending Ghaem Hospital, Mashhad, Iran.</p> <p style="text-align: justify;"><em><strong>Methods:</strong></em> Forty-nine patients, aged 10 to 50 years, with asthma in moderate or severe stages, and 24 healthy controls, were enrolled in this study. After demographic data collection and clinical evaluations, the subjects&rsquo; serum concentrations of Zn, Cu, and Se were measured via atomic absorbency.</p> <p style="text-align: justify;"><em><strong>Results:</strong></em> Mean serum levels of Zn and Se in patients with allergic asthma were lower than in the healthy control group, but the Cu concentration in sera of patients with allergic asthma was slightly higher than healthy controls.</p> <p style="text-align: justify;"><em><strong>Conclusions: </strong></em>Low levels of trace elements, specifically Zn, may have a role in the pathogenesis of allergic asthma; replacement of these elements may be an effective treatment.</p> Asthma, Hyper sensitivity, Trace elements 20 25 http://rbmb.net/browse.php?a_code=A-10-1-60&slc_lang=en&sid=1 Nazila Ariaee 10031947532846006156 10031947532846006156 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Reza Farid 10031947532846006157 10031947532846006157 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Fahimeh Shabestari 10031947532846006158 10031947532846006158 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mohamad Shabestari 10031947532846006159 10031947532846006159 No Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Farahzad Jabbari Azad Jabbarif@mums.ac.ir 10031947532846006160 10031947532846006160 Yes Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran