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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1395 7 1 gregorian 2016 10 1 5 1 online 1 fulltext
en Association of FAS A-670G Polymorphism and Risk of Uterine Leiomyoma in a Southeast Iranian Population زیست شناسی ملکولی Molecular Biology <p style="text-align: justify;"><em><strong>Background:</strong></em> Uterine leiomyoma (UL) is a benign tumor of uterine smooth muscle that affects women in reproductive ages. FAS has an important role in initial stages of apoptosis. Previous studies have shown an association between the FAS gene and tumorigenesis. In the present study, we evaluated the relationship between FAS A-670G (rs 1800682) and UL risk.</p> <p style="text-align: justify;"><em><strong>Methods:</strong></em> The FAS gene polymorphism of 155 women with UL and 157 healthy controls was analyzed by the polymerase chain reaction restriction fragment length polymorphism method.</p> <p style="text-align: justify;"><em><strong>Results:</strong></em> The AA, AG, and GG genotype frequencies of the FAS A-670G polymorphism were respectively 37.4, 42.6, and 20% in women with UL, and 46, 42.6, and 11.5% in healthy controls. The risk of UL in women was 1.5-fold greater in GG-genotype women than in AA-genotype women. The G allele frequencies were 41% in women with UL and 33% in healthy controls and statistically different (P = 0.03).</p> <p style="text-align: justify;"><strong><em>Conclusions:</em></strong> The FAS polymorphism was associated with the risk of UL in a sample of Iranian women.</p> FAS, PCR-RFLP, Polymorphism, Uterine leiomyoma 51 55 http://rbmb.net/browse.php?a_code=A-10-1-65&slc_lang=en&sid=1 Abbas Mohammadpour-Gharehbagh 10031947532846006182 10031947532846006182 No Student Scientific Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Saeedeh Salimi sasalimi@yahoo.com 10031947532846006183 10031947532846006183 Yes Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Farshid Keshavarzi 10031947532846006184 10031947532846006184 No Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Sepideh Zakerian 10031947532846006185 10031947532846006185 No Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mojtaba Sajadian 10031947532846006186 10031947532846006186 No Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mojgan Mokhtari 10031947532846006187 10031947532846006187 No Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.