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en Association of a Genetic Variant in the Cyclin-Dependent Kinase Inhibitor 2B with Risk of Pancreatic Cancer زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;">Background: Pancreatic cancer (PC) is among the most aggressive tumors with a poor prognosis, indicating the need for the identification of a novel prognostic biomarker for risk stratifications. Recent genome-wide association studies have demonstrated common genetic variants in a region on chromosome 9p21 associated with an increased risk of different malignancies. Methods: In the present study, we explore the possible relationship between genetic variant, rs10811661, and gene expression of CDKN2B in 75 pancreatic cancer patients, and 188 healthy individuals. DNAs were extracted and genotyping and gene expression were performed by TaqMan real-time PCR and RT-PCR, respectively. Logistic regression was used to assess the association between risk and genotypes, while the significant prognostic variables in the univariate analysis were included in multivariate analyses. Results: The patients with PDAC had a higher frequency of a TT genotype for rs10811661 than the control group. Also, PDAC patients with dominant genetic model, (TT + TC), was associated with increased risk of developing PDAC (OR= 14.71, 95% CI [1.96-110.35], p= 0.009). Moreover, patients with CC genotype had a higher expression of CDKN2B, in comparison with TT genotype. Conclusions: Our findings demonstrated that CDKN2A/B was associated with the risk of developing PDAC, supporting further investigations in the larger and multicenter setting to validate the potential value of this gene as an emerging marker for PDAC.</div> CDKN2A/B, Rs10811661, Pancreatic cancer, Prognostic biomarker. 336 343 http://rbmb.net/browse.php?a_code=A-10-969-1&slc_lang=en&sid=1 Newsha Sardarzade 100319475328460012285 100319475328460012285 No Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh khojasteh-Leylakoohi 100319475328460012286 100319475328460012286 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Sedigheh Damavandi 100319475328460012287 100319475328460012287 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Ghazaleh Khalili-Tanha 100319475328460012288 100319475328460012288 No Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran & Medical Genetics Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Dashtiahangar 100319475328460012289 100319475328460012289 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Nima Khalili-Tanha 100319475328460012290 100319475328460012290 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran. Amir Avan 100319475328460012291 100319475328460012291 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran & Medical Genetics Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Sakineh Amoueian 100319475328460012292 100319475328460012292 No Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Seyed Mahdi Hassanian 100319475328460012293 100319475328460012293 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Habibollah Esmaily 100319475328460012294 100319475328460012294 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Majid Khazaei 100319475328460012295 100319475328460012295 No Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran & Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Gordon Ferns 100319475328460012296 100319475328460012296 No Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. Alireza Khooei KhooeiAR@mums.ac.ir 100319475328460012297 100319475328460012297 No Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mohsen Aliakbarian AliakbarianM@mums.ac.ir 100319475328460012298 100319475328460012298 Yes Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.