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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1401 8 1 gregorian 2022 11 1 11 3 online 1 fulltext
en Association Between HOTAIR rs920778 and H19 rs3741219 Polymorphisms with Hashimoto’s Thyroiditis (HT) and Graves’ Disease (GD) زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Background: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">Graves&rsquo; disease (GD) and Hashimoto&rsquo;s thyroiditis (HT) are two autoimmune thyroid&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">diseases (AITDs). The current study aimed to assess possible association between HOTAIR rs920778&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">and H19 rs3741219 polymorphisms with GD and HT.</span></span></span><br> &nbsp;</div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Methods: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">We recruited 248 patients with autoimmune thyroid disease (133 HT patients and 115 GD&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">patients) and 135 age- and sex-matched controls. The PCR-RFLP method was applied for genotyping&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">of HOTAIR rs920778, and H19 rs3741219 polymorphisms.</span></span></span><br> &nbsp;</div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Results: </span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">The HOTAIR rs920778 GA frequency was significantly higher in control compared to HT&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">group. The Overdominant model showed a significant association with the risk of HT. However, no&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">significant association was observed between this polymorphism and HT susceptibility in dominant&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">and recessive models. The H19 rs3741219 GA was more repeated in HT patients compared to control </span></span></span></div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">group, but the difference was not significant. There was no association between HOTAIR rs920778&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">and H19 rs3741219 polymorphisms with GD in all genetic models.</span></span></span><br> &nbsp;</div> <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:TimesNewRomanPS-BoldItalicMT"><span style="color:#000000"><span style="font-weight:bold"><span style="font-style:italic">Conclusions:</span></span></span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">Our findings indicated that HOTAIR rs920778 polymorphism decreased the risk of HT.&nbsp;</span></span></span><span style="font-size:12pt"><span style="font-family:Times New Roman"><span style="color:#000000">Since, this the first study, further studies with different races are required to confirm our results. </span></span></span></div> <div style="text-align: justify;"></div> Hashimoto’s thyroiditis, Graves’ disease, HOTAIR, H19, Polymorphism 377 385 http://rbmb.net/browse.php?a_code=A-10-938-2&slc_lang=en&sid=1 Alireza Beiramzadeh 100319475328460013363 100319475328460013363 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran Zahra Heidari 100319475328460013364 100319475328460013364 No Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mahtab Norozi 100319475328460013365 100319475328460013365 No Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. Mohsen Saravani moh.saravani@gmail.com 100319475328460013366 100319475328460013366 Yes Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan,Iran.