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Reports of Biochemistry and Molecular Biology
rbmb.net
Basic Sciences
http://rbmb.net
1
admin
2322-3480
2322-3480
10.61882/rbmb
en
jalali
1401
8
1
gregorian
2022
11
1
11
3
online
1
fulltext
en
Comparison of Serum Changes of Interleukin-17A and Interleukin-21 Between Schizophrenic Patients and Healthy Individuals
بیوشیمی
Biochemistry
مقالات اصلی
Original Article
<div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Immunological alterations in schizophrenic patients have been considered during last decade. There are no remarkable reports on the changes of IL-17A and IL-21 in schizophrenic patients. Therefore, the purpose of this study was to evaluate changes of serum IL-17A and IL-21 in schizophrenic patients in comparison with healthy controls.</span></span></span></span></span></span><br>
<br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">In the present study serum levels of IL-17A and IL-21 in 30 patients with schizophrenia before treatment and three months after treatment were measured by enzyme-linked immunosorbent assay (ELISA) and compare to 30 match healthy control group.</span></span></span></span></span></span><br>
<br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Serum levels of IL-21 in schizophrenic patient was significantly higher than control group (P= 0.001). Serum levels of IL-17A in the schizophrenic patients had no significant changes than the control group (P= 0.4). Serum levels of IL-17A in patients with schizophrenia three months after treatment than before treatment had no significant change (P=0.7) and IL-21 serum levels in schizophrenic patient three month after treatment was not significant changed in comparison with this group before treatment (P= 0.06).</span></span><br>
<b><span dir="RTL" lang="FA" style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></b></span></span></span></span><br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusions:</span></span></i></b> <span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The serum levels of interlukine-21 is elevated in schizophrenic. Results of this study showed that IL-21 might be involved in the pathologic mechanism of schizophrenia.</span></span></span></span></span></span></div>
Keywords: Immunity, Interleukin-17A, Interleukin-21, Schizophrenia.
465
470
http://rbmb.net/browse.php?a_code=A-10-1009-1&slc_lang=en&sid=1
Seyed Ali
Miresmaeili Mazrakhondi
Seyyed.ali.miresmaeily136568@gmail.com.
100319475328460016734
100319475328460016734
Yes
Department of Biology, Faculty of Basic Science, Yazd University, Yazd, Iran.
Hadi
Zare-Zardini
100319475328460016735
100319475328460016735
No
Department of Biomedical Engineering, Meybod University, Meybod, Iran & Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran & Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.