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en Importance of Microminerals for Maintaining Antioxidant Function after COVID-19-induced Oxidative Stress بیوشیمی Biochemistry مقالات اصلی Original Article <div style="text-align: justify;">Background: COVID-19 is caused by the Severe Acute Respiratory Distress Syndrome Coronavirus 2. Since the antioxidant mechanisms such as glutathione peroxidase or superoxide dismutase are downregulated during infection by the virus, there is an imbalance in the oxidant-antioxidant system. In this study we aimed to identify the effect of COVID-19 on the antioxidant defense mechanism by comparing the concentrations of antioxidants and microminerals in COVID-19 patients and healthy controls. Methods: This cross-sectional analytical study involved 200 patients at Kasturba Hospital, Manipal University. The serum concentrations of antioxidants and minerals were determined to establish the impact of COVID-19 on antioxidants mechanism and nutrient status in COVID-19 patients. Results: The serum concentrations of GPX (10.36 ± 2.70 ≥ 5.82 ± 1.64 mKAT/L, p < 0.0001) and copper (2192.5 ± 449.8 ≥ 782.15 ± 106.5 µg/dL, p < 0.0001) were significantly greater, and zinc (34.78 ± 4.5 ≤ 81.07 ± 10.13 µg/dL, p < 0.0001) was significantly less, in the study group than in controls. The Pearson correlation between serum SOD and zinc was significant (r = 0.491, p < 0.0001) indicating the importance of zinc in maintaining and improving SOD activity. No significant correlations were observed between copper and SOD (r = -0.089) or iron and CAT (r = -0.027). Conclusions: Our study demonstrated the expected increase in oxidant-radical production during COVID-19 by estimating the altered concentrations of antioxidants and the minerals required to neutralize the elevated ROS. This finding is not novel but adds to the existing literature, which recommends nutritional supplementation of microminerals and antioxidants.</div> Keywords: COVID-19, Cytokines, Glutathione Peroxidase, Minerals, Reactive oxygen species, Zinc. 479 486 http://rbmb.net/browse.php?a_code=A-10-1047-1&slc_lang=en&sid=1 Ravindra Maradi 100319475328460016742 100319475328460016742 No Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Vivek Joshi VJ93@drexel.edu 100319475328460016743 100319475328460016743 Yes Department of Biochemistry and Molecular Biology, Drexel University college of Medicine, Innovation Way, Wyomissing, 19610, Pennsylvania, USA. Vaideki Balamurugan 100319475328460016744 100319475328460016744 No Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Divya Susan Thomas 100319475328460016745 100319475328460016745 No Department of Biochemistry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Manjunath Goud 100319475328460016746 100319475328460016746 No Department of Biochemistry, RAK Medical & Health sciences University, Ras al Khaimah, UAE.