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'); Reports of Biochemistry and Molecular Biology rbmb.net Basic Sciences http://rbmb.net 1 admin 2322-3480 2322-3480 10.61882/rbmb en jalali 1401 8 1 gregorian 2022 11 1 11 3 online 1 fulltext
en Investigation of the Frequency and Type of Chromosomal Abnormalities in Women Patients with Amenorrhea زیست شناسی ملکولی Molecular Biology مقالات اصلی Original Article <div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Background: </span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Amenorrhea is defined as the absence of menstruation at the reproductive age of women. Amenorrhea caused by various etiological factors including genetic factors, intrauterine malformations, endocrine dysfunction, and environmental factors. Genetic factors particularly chromosomal abnormalities are the main cause of Amenorrhea. This study was performed to estimate the frequency and types of chromosomal abnormalities in patients with amenorrhea in the northeast of Iran.</span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Methods: </span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">A total of 381 women with the history of amenorrhea participated in this study. Peripheral blood lymphocyte cultures were performed according to the standard GTG banding method.</span></span><br> <b><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></b></span></span></span></span><br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">296 (77%) of a total of all cases had a normal karyotype (46, XX) while 85 patients (23%) had abnormal karyotype. The numerical and structural abnormalities of X chromosome were observed in 52 (61%), the abnormalities of Y chromosome were observed in 23 (27.2%) and rearrangements between autosomal and/or sex chromosomes were observed in 10 (11.8%).</span></span></span></span></span></span><br> <br> <span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span style="tab-stops:396.55pt"><b><i><span lang="EN-CA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusions: </span></span></i></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">The present study revealed that cytogenetic study is essential for early diagnosis and treatments of Amenorrhea.</span></span></span></span></span></span></div> Keywords: Amenorrhea, Chromosomal Abnormalities, Cytogenetics. 450 456 http://rbmb.net/browse.php?a_code=A-10-353-2&slc_lang=en&sid=1 Neda Motamedirad 100319475328460016725 100319475328460016725 No Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Susan Hosseini 100319475328460016726 100319475328460016726 No Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Reza Ebrahimzadeh-Vesal 100319475328460016727 100319475328460016727 No Pardis Clinical and Genetics Laboratory, Mashhad, Iran & Medical Genetics Research Center, Medical School, Mashhad University Medical Sciences, Mashhad, Iran. Semiramis Tootian 100319475328460016728 100319475328460016728 No Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. MohammadReza Abbaszadegan 100319475328460016729 100319475328460016729 Yes Pardis Clinical and Genetics Laboratory, Mashhad, Iran & Immunology Research Center, Mashhad University Medical Sciences, Mashhad, Iran.