Volume 6, Issue 1 (Vol.6 No.1 Oct 2017)                   rbmb.net 2017, 6(1): 112-117 | Back to browse issues page

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Tavakkol Afshari Z, Nikpoor A R, Tavvakol Afshari J, Ganjali R, Sanglakh Ghoochan Atigh P, Homaei Shandiz F et al . Lack of an Association between a Functional Polymorphism in the MDM2 Promoter and Breast Cancer in Women in Northeast Iran. rbmb.net 2017; 6 (1) :112-117
URL: http://rbmb.net/article-1-117-en.html
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (6822 Views)

Background: Breast cancer is one of the most common cancers among women worldwide. Tumor protein 53 (TP53) and its regulator the mouse double murine 2 (MDM2) have important roles in tumorigenesis by playing key roles in cell division and response to DNA damage. MDM2 SNP309 T>G (rs2279744) polymorphism in the promoter region of MDM2 gene can cause dysfunction and inactivation of TP53 which promote tumor progression as a result. The aim of this study was to investigate the association between this polymorphism and risk of breast cancer in northeastern Iranian population.

Material: A case-control study with 128 breast cancer patients and 143 healthy women was conducted. PCR-ARMS was performed to assess the MDM2 SNP309 T>G (rs2279744) polymorphism.

Results: The GG Genotype frequency between patients and controls showed no significant association between this polymorphism with breast cancer risk (p=0.116, OR [95% CI]: 1.267 [0.616, 2.603]). Also, G allele frequency was not associated with breast cancer risk in studied population (p=0.143, OR [95% CI]: 1.326 [0.908, 1.935]). For this polymorphism, a significant difference of 8.0 years in the average age of cancer diagnosis was observed between TT and TG carriers (40.57 versus 48.15 years, p = 0.029).

Conclusion: The results of this study suggest that the SNP309 T>G polymorphism in the MDM2 gene may not be associated with the risk of breast cancer in an Iranian population

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Type of Article: Original Article | Subject: Molecular Biology
Received: 2016/12/11 | Accepted: 2017/03/25 | Published: 2017/07/3

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