Volume 7, Issue 1 (Vol.7 No.1 Oct 2018)                   rbmb.net 2018, 7(1): 1-8 | Back to browse issues page

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Yousefinejad A, Siassi F, Javanbakht M H, Mohammadi H, Ghaedi E, Zarei M, et al . Effect of Genistein and L-carnitine and Their Combination on Lipid Profile and Inflammatory Cytokines in Experimental Nephrotic Syndrome. rbmb.net. 2018; 7 (1) :1-8
URL: http://rbmb.net/article-1-160-en.html
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Abstract:   (2688 Views)

Background: Nephrotic syndrome is a disorder caused by kidney damage that results in severe leakage of protein from blood into urine. Hyperlipidemia is one complication of nephrotic syndrome. L-carnitine and genistein can control cardiovascular diseases by causing changes in lipid metabolism and cytokine production. This study was designed to examine the effects of genistein and L-carnitine on serum lipid and cytokine profiles in experimental nephrotic syndrome.

Methods: In this study, 50 male Sprague–Dawley rats were randomly divided into five groups of 10 animals each with similar mean body weights (300±50 g). The five groups were NC (normal-control), PC (patient-control), LC (L-carnitine), G (genistein), and LCG (L-carnitine-genistein). Serum HDL-cholesterol (HDL) LDL-cholesterol (LDL), triglyceride, cholesterol, IL-6, and TNF-α were measured. Statistics were analyzed using SPSS 18.0. 

Results: At the end of the study, of the patient groups, HDL was significantly greater in the LC than in the PC or G groups (P<0.001). LDL was significantly less in the G than in the PC, LC, or LCG groups (P<0.001). Interleukin-6 was significantly greater in the PC than in the LC, G, or LCG groups, and significantly greater in the LC than in the G group. (P<0.001), but no significant differences were found for triglyceride, cholesterol, or TNF-α between the patient groups.

Conclusions: Genistein had less effect on HDL and triglyceride levels than LC or LCG. Regarding inflammatory cytokines, genistein and L-carnitine had less effect on TNF-α than on IL-6.

Full-Text [PDF 467 kb]   (1262 Downloads)    
Type of Article: Original Article | Subject: Molecular Biology
Received: 2017/04/22 | Accepted: 2017/10/12 | Published: 2018/01/27

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