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Mohamad M, Ebeid S, Khater M S, Alsadany M. Interferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly. rbmb.net. 2018; 7 (1) :52-58
URL: http://rbmb.net/article-1-220-en.html
Medical Biochemistry Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract:   (96 Views)
Background: Chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. Interferon-gamma (INF-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (GTP-CH1) pathway. Our aim was to evaluate the GTP-CH1 pathway in Egyptian frail elderly subjects.

Methods: INF-γ, neopterin, and nitric oxide (NO) levels were measured in 80 participants.

Results: Both pre-frail and frail subjects had significantly higher levels of INF-γ, neopterin and lower levels of NO than the control group. These biomarkers were associated with the risk of frailty with significant odds ratio.

Conclusions: Elevated INF-γ levels in frail subjects may activate the GTP-CH1 pathway. Elevated neopterin and reduced NO levels correlated with an active GTP-CH1 pathway. The risk of frailty increased with elevated INF-γ and neopterin and decreased with elevated NO levels.
Full-Text [PDF 515 kb]   (29 Downloads)    
Type of Article: Original Article | Subject: Biochemistry
Received: 2018/01/26 | Accepted: 2018/02/26 | Published: 2018/04/2

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