Volume 8, Issue 3 (Vol.8 No.3 Oct 2019)                   rbmb.net 2019, 8(3): 253-259 | Back to browse issues page

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Panduranga Shenoy R, Hanumaiah G, Bolar Suryakanth V, Shridharan P. Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) Patients. rbmb.net. 2019; 8 (3) :253-259
URL: http://rbmb.net/article-1-326-en.html
Department of Biochemistry, Kasturba Medical College Manipal, Manipal Academy of Higher Education Manipal, Karnataka, India.
Abstract:   (370 Views)
Background: The study aims at the comparison and correlation of serum levels of fructosamine and erythrocyte Na+/ K+ ATPase in Gestational diabetes mellitus (GDM) and Non Gestational Diabetes Mellitus (Non GDM).

Methods: A total of 326 samples were divided into 4 groups. Pregnant women between the age group of 20-40 years who gave samples for Oral Glucose Tolerance Test (OGTT) were included as the subjects. Anonymized and left over fasting and 2 hours’ samples were collected from biochemistry laboratory, Kasturba Hospital, Manipal.

Results: In the comparison of fructosamine levels in GDM and Non GDM, fructosamine was found to be significant (p value<0.001) in both fasting and 2 hours (G2) blood glucose condition. Na+/ K+ ATPase did not show any significant variation between the groups. Correlation was not significant between the parameters.

Conclusions: Fructosamine showed significant increase when compared between the groups, whereas significant correlation is not obtained between the parameters. Thus, the use fructosamine as a diagnosis tool becomes inconclusive. Further studies must be carried out to identify a marker which reduces the interferences observed in fructosamine and to find out the exact relationship between hyperglycaemia and Na+/ K+ ATPase activity.
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Type of Article: Original Article | Subject: Biochemistry
Received: 2019/02/27 | Accepted: 2019/04/7 | Published: 2020/01/24

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