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Yaghoubi Hariri F, Salahshourifar I, Zare Karizi S. Association between Coronary Artery Disease and rs10757278 and rs1333049 Polymorphisms in 9p21 Locus in Iran. rbmb.net. 2020; 9 (1) :58-63
URL: http://rbmb.net/article-1-492-en.html
Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Abstract:   (333 Views)
Background: Coronary arteries disease (CAD) has been recognized as one of the most common causes of death worldwide, with an estimated seven million deaths annually.

Methods: Two hundred blood samples from Iranian CAD patients and normal healthy controls were collected. CAD and the 9p21 locus variants rs1333049 and rs10757278 were analyzed for potential associations.

Results: No significant differences in rs10757278 and rs1333049 polymorphisms were found between patients and controls, but a significant relationship was found between rs10757278 and rs1333049 in CAD patients at the genotype level (p= 0.0323). At the haplotype level and on the basis of diplotype analysis, a significant relationship was found between patients and controls (OR= 5.16, p= 0.047, 95% CI: 1.02-26.0). In CAD patients, rs10757278 and rs1333049 were associated at locus 9p21.

Conclusions: The inconsistency between the results of this and other studies on different CAD populations may be due to high population, different ethnicities, low prevalence of some alleles in populations, and interactions of different genes.
Full-Text [PDF 247 kb]   (103 Downloads)    
Type of Article: Case Report | Subject: Molecular Biology
Received: 2020/04/23 | Accepted: 2020/05/21 | Published: 2020/05/19

References
1. Mackay J, Mensah G, Mendis S, Greenlund K. The atlas of heart disease and stroke. World Health Organization Department of Management of Noncommunicable Diseases. Geneva: World Health Organization; 2004.
2. Khosropanah SH, Tahmasebi J, Zibaeenezhad MJ, Heydari ST, Zamirian M, Aghasadeghi K, et al. Prevalence of Coronary Artery Disease Risk factors in Teachers Residing in Shiraz-Iran 2009.  Iranian Cardiovascular Research Journal. 2010;4(2):50-54.
3. Rachel H. Risk Factors for Coronary Artery Disease. Historical Perspectives. 2017;18(3):109-114. [DOI:10.4103/HEARTVIEWS.HEARTVIEWS_106_17] [PMID] [PMCID]
4. Cohen R, Budoff M, McClelland RL, Sillau S, Burke G, Blaha M, et al. Significance of a positive family history for coronary heart disease in patients with a zero coronary artery calcium score (from the multi-ethnic study of atherosclerosis). Am J Cardiol. 2014;114(8):1210-4. [DOI:10.1016/j.amjcard.2014.07.043] [PMID] [PMCID]
5. Morgan TM, Krumholz HM, Lifton RP, Spertus JA. Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA. 2007;297(14):1551-61. [DOI:10.1001/jama.297.14.1551] [PMID]
6. Naif A. The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism. Taibah University Medical Sciences. 2017;12(3): 199-204. [DOI:10.1016/j.jtumed.2017.03.001] [PMID] [PMCID]
7. Musunuru K. Enduring mystery of the chromosome 9p21.3 locus. Circ Cardiovasc Genet. 2013;6(2):224-5. [DOI:10.1161/CIRCGENETICS.113.000132] [PMID]
8. Brian G, Rasika A, Bhoom S, Ingo R, Dhananjay V, Lisa R , et al. A common variant in the CDKN2B gene on chromosome 9p21 protects against coronary artery disease in Americans of African ancestry. J Hum Genet. 2011;56(3):224-9. [DOI:10.1038/jhg.2010.171] [PMID] [PMCID]
9. Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I. Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 2007;67(8):3963-9. [DOI:10.1158/0008-5472.CAN-06-2004] [PMID]
10. Kaur N, Singh J, Reddy S. ANRI rs1333049 C/G polymorphism and coronary artery disease in a North Indian population- Gender and age specific associations. Genet Mol Biol. 2020;43(1):e20190024. [DOI:10.1590/1678-4685-gmb-2019-0024] [PMID] [PMCID]
11. Harismendy O, Notani D, Song X, Rahim NG, Bogdan T9, Heintzman N, et al. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011;470(7333):264-8. [DOI:10.1038/nature09753] [PMID] [PMCID]
12. Shu Ye, Sahar Dhillon, Xiayi Ke, Andrew RC, Ian NMD. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res. 2001;29(17):e88. [DOI:10.1093/nar/29.17.e88] [PMID] [PMCID]
13. Alzohairy A. (2011). BioEdit: An important software for molecular biology. GERF Bulletin of Biosciences.2011;2(1):60-61.
14. Mozaffarian D, Benjamin EJ, et al. Executive Summary: Heart Disease and Stroke Statistics- 2016 Update: A Report from the American Heart Association. Circulation. 2016;133(4):447-54. https://doi.org/10.1161/CIR.0000000000000366 [DOI:10.1161/CIR.0000000000000350] [PMID]
15. Won H, Natarajan P, Dobbyn A, Jordan DM, Roussos P, Lage K, et al. Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease. PLoS Genet. 2015;11(10):e1005622. [DOI:10.1371/journal.pgen.1005622] [PMID] [PMCID]
16. Huseyin AC, Burcu B, Eser D, Gunay C, Bilgehan K, Mujgan C, et al. Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population. Anatol J Cardiol. 2015;15(3):196-203. [DOI:10.5152/akd.2014.5285] [PMID] [PMCID]
17. Popov N, Gil J. Epigenetic regulation of the INK4b-ARF-INK4a locus: in sickness and in health. Epigenetics. 2010;5(8):685-690. [DOI:10.4161/epi.5.8.12996] [PMID] [PMCID]
18. Cakmak HA, Bayoglu B, Durmaz E, Can G, Karadag B, Cengiz M, et al. Evaluation of association between common genetic variants on chromosome 9p21 and coronary artery disease in Turkish population. Anatol J Cardiol. 2015;15(3):196-203. [DOI:10.5152/akd.2014.5285] [PMID] [PMCID]
19. Foroughmand A, Nikkhah E, Galehdari H, Jadbabaee M. Association Study between Coronary Artery Disease and rs1333049 and rs10757274 Polymorphisms at 9p21 Locus in South-West Iran. Cell J.2015;17(1):89-98.
20. Niemiec P, Gorczynska-Kosiorz S, Iwanicki T, Krauze J, Trautsolt W, Grzeszczak W, et al. The rs10757278 Poly-morphism of the 9p21.3 Locus Is Associated with Premature Coronary Artery Disease in Polish Patients. Genet Test Mol Biomarkers. 2012;16(9):1080-5. [DOI:10.1089/gtmb.2012.0046] [PMID] [PMCID]
21. Riyaz S, Folkert WA, Arshed AQ, Tom MP, Chris IF, Vinicius T, at al.Genetic Variants at Chromosome 9p21 and Risk of First Versus Subsequent Coronary Heart Disease Events: A Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2014;63(21):2234-45. [DOI:10.1016/j.jacc.2014.01.065] [PMID] [PMCID]
22. Kashyap S, Kumar S, Agarwal V, Misra D, Rai M, Kapoor A. The association of polymorphic variants, rs2267788, rs1333049 and rs2383207 with Coronary Artery Disease, its severity and presentation in North Indian Population. Gene. 2018;648:89-96. [DOI:10.1016/j.gene.2018.01.021] [PMID]

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