Reports of Biochemistry
and Molecular Biology
Mon, Jul 7, 2025
[Archive]
Volume 9, Issue 4 (Vol.9 No.4 Jan 2021)
rbmb.net 2021, 9(4): 399-407 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Davoodi A, Lotfi R, Mortazavi S H, Gorgin Karaji A, Rezaiemanesh A, Salari F. Retinoic Acid Correlates with Reduced Serum IL-10 And TGF-β in Allergic Rhinitis. rbmb.net 2021; 9 (4) :399-407
URL: http://rbmb.net/article-1-545-en.html
URL: http://rbmb.net/article-1-545-en.html
Akram Davoodi 
, Ramin Lotfi , Seyed Hamidreza Mortazavi , Ali Gorgin Karaji , Alireza Rezaiemanesh , Farhad Salari *
, Ramin Lotfi , Seyed Hamidreza Mortazavi , Ali Gorgin Karaji , Alireza Rezaiemanesh , Farhad Salari *
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract: (4454 Views)
Background: Retinoic acid (RA) plays a key role in naïve T cell differentiation into FOXP3+ Treg cell in the respiratory airways. The present study aims to investigate RA and Treg-related cytokine serum levels, salivary IgA levels, FOXP3 and IL-4 gene expression, and the relationships between RA serum levels and Treg-related cytokines in allergic rhinitis (AR) patients and healthy controls.
Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls.
Results: IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients.
Conclusions: Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
Methods: Salivary IgA and serum IgE, RA, IL-10, and TGF-β concentrations were measured by ELISA in 37 AR patients and 30 age- and sex-matched healthy controls.
Results: IL-10 and TGF-β concentrations were significantly less in AR patients than in healthy controls (p< 0.01 and P< 0.0001, respectively). Salivary IgA was significantly greater in patients than in controls (p< 0.05). RA was not significantly different between patients and controls (p> 0.05); however, a significant positive correlation was found between serum RA and both IL-10 and TGF-β in AR patients.
Conclusions: Our data suggest that RA may influence AR risk via affecting the TGF-β and IL-10 production.
Type of Article: Original Article |
Subject:
Immunology
Received: 2020/08/13 | Accepted: 2020/09/1 | Published: 2021/03/8
Received: 2020/08/13 | Accepted: 2020/09/1 | Published: 2021/03/8
References
1. Chong SN, Chew FT. Epidemiology of allergic rhinitis and associated risk factors in Asia. World Allergy Organ J. 2018;11(1):17. [DOI:10.1186/s40413-018-0198-z] [PMID] [PMCID]
2. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol. 2008;122(2 Suppl):S1-84. [DOI:10.1016/j.jaci.2008.06.003] [PMID]
3. Shirkani A, Mansouri A, Farid Hosseini R, Jabbari Azad F, Alsadat Mahmoudian R, Montazer M, et al. The Role of Interleukin-4 and 13 Gene Polymorphisms in Allergic Rhinitis: A Case Control Study. Rep Biochem Mol Biol. 2019;8(2):111-118.
4. Gray T, Koo J-S, Nettesheim P. Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium. Toxicology. 2001;160(1-3):35-46. [DOI:10.1016/S0300-483X(00)00455-8]
5. Weaver CT, Hatton RD. Interplay between the T H 17 and T Reg cell lineages: a (co-) evolutionary perspective. Nat Rev Immunol. 2009;9(12):883-9. [DOI:10.1038/nri2660] [PMID]
6. Strauss L, Bergmann C, Szczepanski M, Gooding W, Johnson JT, Whiteside TL. A unique subset of CD4+ CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-β1 mediates suppression in the tumor microenvironment. Clin Cancer Res. 2007;13(15 Pt 1):4345-54. [DOI:10.1158/1078-0432.CCR-07-0472] [PMID]
7. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nature immunology. 2005;6(4):338-334. [DOI:10.1038/ni1180] [PMID]
8. Mora JR, Iwata M, Eksteen B, Song S-Y, Junt T, Senman B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006;314(5802):1157-60. [DOI:10.1126/science.1132742] [PMID]
9. Schwartz DP, Buckley RH. Serum IgE concentrations and skin reactivity to anti-IgE antibody in IgA-deficient patients. New England Journal of Medicine. 1971;284(10):513-7. [DOI:10.1056/NEJM197103112841002] [PMID]
10. Taylor B, Norman A, Orgel H, Turner M, Stokes C, Soothill J. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973;302(7821):111-3. [DOI:10.1016/S0140-6736(73)93060-2]
11. Denburg JA, Sehmi R, Upham J, Wood L, Gauvreau G, O'Byrne P. Regulation of IL-5 and IL-5 Receptor Expression in the Bone Marrow of Allergic Asthmatics. Int Arch Allergy Immunol. 1999;118(2-4):101-3. [DOI:10.1159/000024040] [PMID]
12. Denburg JA, Sehmi R, Upham J. Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid. Int Arch Allergy Immunol. 2001;124(1-3):246-8. [DOI:10.1159/000053724] [PMID]
13. Tokuyama H, Tokuyama Y, Nakanishi K. Retinoids inhibit IL-4-dependent IgE and IgG1 production by LPS-stimulated murine splenic B cells. Cellular immunology. 1995;162(1):153-158. [DOI:10.1006/cimm.1995.1063] [PMID]
14. Ross AC. Vitamin A and retinoic acid in T cell-related immunity. Am J Clin Nutr. 2012;96(5):1166S-1172S. [DOI:10.3945/ajcn.112.034637] [PMID] [PMCID]
15. Cantorna MT, Nashold FE, Hayes CE. Vitamin A deficiency results in a priming environment conducive for Th1 cell development. Eur J Immunol. 1995;25(6):1673-9. [DOI:10.1002/eji.1830250629] [PMID]
16. Son H-L, Park H-R, Park Y-J, Kim S-W. Effect of retinoic acid in a mouse model of allergic rhinitis. Allergy Asthma Immunol Res. 2015;7(6):590-598. [DOI:10.4168/aair.2015.7.6.590] [PMID] [PMCID]
17. Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, et al. Japanese guideline for allergic rhinitis. Allergology International. 2011;60(2):171-89. [DOI:10.2332/allergolint.11-RAI-0334] [PMID]
18. Karagiannidis C, Akdis M, Holopainen P, Woolley NJ, Hense G, Rückert B, et al. Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma. J Allergy Clin Immunol. 2004;114(6):1425-33. [DOI:10.1016/j.jaci.2004.07.014] [PMID]
19. Ling EM, Smith T, Nguyen XD, Pridgeon C, Dallman M, Arbery J, et al. Relation of CD4+ CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet. 2004;363(9409):608-15. [DOI:10.1016/S0140-6736(04)15592-X]
20. Grindebacke H, Wing K, Andersson AC, Suri‐Payer E, Rak S, Rudin A. Defective suppression of Th2 cytokines by CD4+ CD25+ regulatory T cells in birch allergics during birch pollen season. Clin Exp Allergy. 2004;34(9):1364-72. [DOI:10.1111/j.1365-2222.2004.02067.x] [PMID]
21. Ruhl R, Garcia A, Schweigert FJ, Worm M. Modulation of cytokine production by low and high retinoid diets in ovalbumin-sensitized mice. Int J Vitam Nutr Res. 2004;74(4):279-84. [DOI:10.1024/0300-9831.74.4.279] [PMID]
22. Iwata M, Eshima Y, Kagechika H. Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int Immunol. 2003;15(8):1017-25. [DOI:10.1093/intimm/dxg101] [PMID]
23. Matheu V, Barrios Y, Berggrd K, Baeza M, Zubeldia J, Back O, Issazadeh-Navikas S. Influence of retinoic acid in allergic inflammation. Annals of Allergy Asthma & Immunology 98: 1. A83-A83.
24. Milner JD, Stein DM, McCarter R, Moon RY. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics. 2004;114(1):27-32. [DOI:10.1542/peds.114.1.27] [PMID]
25. Kull I, Bergström A, Melén E, Lilja G, van Hage M, Pershagen G, et al. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. J Allergy Clin Immunol. 2006;118(6):1299-304. [DOI:10.1016/j.jaci.2006.08.022] [PMID]
26. Lúðvíksson B, Arason G, Thorarensen O, Ardal B, Valdimarsson H. Allergic diseases and asthma in relation to serum immunoglobulins and salivary immunoglobulin A in pre‐school children: a follow‐up community‐based study. Clin Exp Allergy. 2005;35(1):64-9. [DOI:10.1111/j.1365-2222.2005.02141.x] [PMID]
27. Calvo M, Grob K, Marín F, Bertoglio J, Neira J, Arellano P, et al. Evaluation of secretory IgA childhood respiratory diseases. Allergol Immunopathol (Madr). 1988;16(3):157-61.
28. Payette K, Weiss N. Salivary IgA levels in atopic children. Annals of allergy. 1977;39(5):328-31.
29. Van Asperen P, Gleeson M, Kemp A, Cripps A, Geraghty S, Mellis C, et al. The relationship between atopy and salivary IgA deficiency in infancy. Clin Exp Immunol. 1985;62(3):753-757.
30. Stokes C, Taylor B, Turner M. Association of house-dust and grass-pollen allergies with specific IgA antibody deficiency. The Lancet. 1974;304(7879):485-488. [DOI:10.1016/S0140-6736(74)92014-5]
31. Gleeson M, Clancy RL, Hensley MJ, Cripps AW, Henry RL, Wlodarczyk JH, et al. Development of bronchial hyperreactivity following transient absence of salivary IgA. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1785-9. [DOI:10.1164/ajrccm.153.6.8665035] [PMID]
32. Martino D, Currie H, Taylor A, Conway P, Prescott S. Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development. Clin Exp Allergy. 2008;38(1):69-78.
33. Brown MA, Hural J. Functions of IL-4 and Control of Its Expression. Crit Rev Immunol. 1997;17(1):1-32. [DOI:10.1615/CritRevImmunol.v17.i1.10] [PMID]
34. Yano N, Endoh M, Miyazaki M, Yamauchi F, Nomoto Y, Sakai H. Altered production of IgE and IgA induced by IL‐4 in peripheral blood mononuclear cells from patients with IgA nephropathy. Clin Exp Immunol. 1992;88(2):295-300. [DOI:10.1111/j.1365-2249.1992.tb03076.x] [PMID] [PMCID]
35. Böttcher M, Häggström P, Björksten B, Jenmalm M. Total and allergen‐specific immunoglobulin A levels in saliva in relation to the development of allergy in infants up to 2 years of age. Clin Exp Allergy. 2002;32(9):1293-8. [DOI:10.1046/j.1365-2222.2002.01470.x] [PMID]
36. Perrier C, Thierry AC, Mercenier A, Corthesy B. Allergen‐specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice. Clin Exp Allergy. 2010;40(1):153-62. [DOI:10.1111/j.1365-2222.2009.03329.x] [PMID]
37. Ciprandi G, Vizzaccaro A, Cirillo I, Tosca M, Massolo A, Passalacqua G. Nasal eosinophils display the best correlation with symptoms, pulmonary function and inflammation in allergic rhinitis. Int Arch Allergy Immunol. 2005;136(3):266-72. [DOI:10.1159/000083953] [PMID]
38. Chowdary VS, Vinaykumar EC, Rao JJ, Rao R, Babu KR, Rangamani V. A study on serum IgE and eosinophils in respiratory allergy patients. Indian J Allergy Asthma Immunol. 2003;17(1):21-4.
39. Krouse JH, Chadwick SJ, Gordon BR, Derebery MJ. Allergy and immunology: an otolaryngic approach: Lippincott-Williams & Wilkins Philadelphia; 2002.
40. Sybilski AJ, Raciborski F, Lipiec A, Tomaszewska A, Lusawa A, Furmanczyk K, et al. Obesity--a risk factor for asthma, but not for atopic dermatitis, allergic rhinitis and sensitization. Public Health Nutr. 2015;18(3):530-6. [DOI:10.1017/S1368980014000676] [PMID]
41. Baumann S, Lorentz A. Obesity - a promoter of allergy?. Int Arch Allergy Immunol. 2013;162(3):205-13. [DOI:10.1159/000353972] [PMID]
42. Lei Y, Yang H, Zhen L. Obesity is a risk factor for allergic rhinitis in children of Wuhan (China). Asia Pac Allergy. 2016;6(2):101-104. [DOI:10.5415/apallergy.2016.6.2.101] [PMID] [PMCID]
43. Saadeh D, Salameh P, Caillaud D, Charpin D, de Blay F, Kopferschmitt C, et al. High body mass index and allergies in schoolchildren: the French six cities study. BMJ Open Respir Res. 2014;1(1):e000054. [DOI:10.1136/bmjresp-2014-000054] [PMID] [PMCID]
44. Han YY, Forno E, Gogna M, Celedon JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol. 2016;137(5):1460-5. [DOI:10.1016/j.jaci.2015.12.1307] [PMID] [PMCID]
45. Yao TC, Ou LS, Yeh KW, Lee WI, Chen LC, Huang JL. Associations of age, gender, and BMI with prevalence of allergic diseases in children: PATCH study. J Asthma. 2011;48(5):503-10. [DOI:10.3109/02770903.2011.576743] [PMID]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
