Volume 3, Issue 2 (Vol.3 No.2 Apr 2015)                   rbmb.net 2015, 3(2): 82-88 | Back to browse issues page

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Khakzad M R, Salari F, Javanbakht M, Hojati M, Varasteh A, Sankian M et al . Transforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders. rbmb.net. 2015; 3 (2) :82-88
URL: http://rbmb.net/article-1-63-en.html
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Abstract:   (4997 Views)

Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the present study was to investigate the correlation of TGF-β1 polymorphisms and their haplotypes with autism.

Methods: This study was performed on 39 autistic patients and 35 age- and sex-matched normal controls in an Iranian population, using the sequence specific primed-polymerase chain reaction (PCR-SSP) technique. Patients were divided into mild-to-moderate and severe groups according to the childhood autism rating scale.

Results: No significant differences were observed for allele, genotype, or haplotype frequencies between the autistics and controls. Only a slight difference was observed in GC25 between the controls and all children with autism.

Conclusion: Thus, these results indicate that the polymorphisms in TGF-β1 gene may not play an important role in the development of autism.

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Subject: Special
Received: 2014/05/12 | Accepted: 2014/07/17 | Published: 2015/04/30

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