Volume 11, Issue 1 (Vol.11 No.1 Apr 2022)                   rbmb.net 2022, 11(1): 36-43 | Back to browse issues page


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Abdulmahdi Mokif T, Abdul-Ameer Mahdi Z, Tuama Obayes Al- Mammori R, Oleiwi Muttaleb Al-Dahmoshi H, Kadhim Al-Khafaji N S. Correlation of Vitamin D3, PAI-1, and HCG Hormone in Pre- and Post-Menopausal in Babylon Province. rbmb.net 2022; 11 (1) :36-43
URL: http://rbmb.net/article-1-776-en.html
Department of Biology, college of science, university of Babylon, Hilla, Iraq.
Abstract:   (2468 Views)
Background: Menopause is a unique event in women's life it usually occurs naturally, most often after age 50 when woman has not menstruated in 12 consecutive months. This study was planned to assess the relationship between Vitamin D3 level, PAI-1 and HCG in Babylon women at age <50 years as pre-menopausal and> 50 years as post-menopausal.
 
Methods:
The sample were selected from a group of pre- and post-menopausal women, 30 and 50 respectively. All the tests were evaluated to measure Vitamin D3 level, PAI-1 and HCG level. The sample was collected between July 2019 and January 2020 at Merjan medical city GIT and Liver
Center, Babylon province, Iraq.

Results: The result of current study revealed that there are significant differences in vitamin D3 level in various age categories within postmenopausal women (p= 0.02) also there is no significant differences in PAI-1 and HCG with in these two groups, p= 0.08 and 0.07, respectively. Also, there is significant negative correlation between vitamin D3 and PAI-1 in postmenopausal women (p. value is 0.01).

Conclusions: Indeed, postmenopausal women regarded as elderly, but they have sufficient vitamin D3 and normal PAI-I levels as markers for normal non fibrosis status.
Full-Text [PDF 253 kb]   (1080 Downloads)    
Type of Article: Original Article | Subject: Biochemistry
Received: 2021/08/22 | Accepted: 2021/11/29 | Published: 2022/05/26

References
1. Caruso S, Rapisarda AMC, Cianci S. Sexuality in menopausal women. Curr Opin Psychiatry. 2016;29(6):323-30. [DOI:10.1097/YCO.0000000000000280] [PMID]
2. Holick MF. Resurrection of vitamin D deficiency and rickets. J Clin Invest. 2006;116(8):2062-72. [DOI:10.1172/JCI29449] [PMID] [PMCID]
3. Bikle DD. Vitamin D: Production, Metabolism and Mechanisms of Action. In: Feingold KR, Anawalt B, Boyce A, et al., editors. Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000.
4. DeLuca HF. Evolution of our understanding of vitamin D. Nutr Rev. 2008;66(10 Suppl 2):S73-87. [DOI:10.1111/j.1753-4887.2008.00105.x] [PMID]
5. Zhu J, DeLuca HF. Vitamin D 25-hydroxylase - Four decades of searching, are we there yet?. Arch Biochem Biophys. 2012;523(1):30-6. [DOI:10.1016/j.abb.2012.01.013] [PMID]
6. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: A population-based study in older men and women. J Clin Endocrinol Metab. 2005;90(7):4119-23. [DOI:10.1210/jc.2005-0216] [PMID]
7. Pfotenhauer KM, Shubrook JH. Vitamin D deficiency, its role in health and disease, and current supplementation recommendations. J Am Osteopath Assoc. 2017;117(5):301-305. [DOI:10.7556/jaoa.2017.055] [PMID]
8. De Taeye B, Smith LH, Vaughan DE. Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease. Curr Opin Pharmacol. 2005;5(2):149-54. [DOI:10.1016/j.coph.2005.01.007] [PMID]
9. Fortenberry YM. Plasminogen activator inhibitor-1 inhibitors: a patent review (2006-present). Expert Opin Ther Pat. 2013;23(7):801-15. [DOI:10.1517/13543776.2013.782393] [PMID]
10. Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol. 2002;3(12):932-43. [DOI:10.1038/nrm977] [PMID]
11. Zhang L, Seiffert D, Fowler BJ, Jenkins GR, Thinnes TC, Loskutoff DJ, et al. Plasminogen has a broad extrahepatic distribution. Thromb Haemost. 2002;87(3):493-501. [DOI:10.1055/s-0037-1613030] [PMID]
12. Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, et al. Crystal structure of human chorionic gonadotropin. Nature. 1994;369(6480):455-61. [DOI:10.1038/369455a0] [PMID]
13. Cole LA. Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites. Clin Chem. 1997;43(12):2233-43. [DOI:10.1093/clinchem/43.12.2233] [PMID]
14. Stenman UH, Tiitinen A, Alfthan H, Valmu L. The classification, functions and clinical use of different isoforms of HCG. Hum Reprod Update. 2006;12(6):769-84. [DOI:10.1093/humupd/dml029] [PMID]
15. Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra-Morales Y, López-González B, Miralles-Adell C, et al. Response of vitamin D after magnesium intervention in a postmenopausal population from the province of Granada, Spain. Nutrients. 2020;12(8):2283. [DOI:10.3390/nu12082283] [PMID] [PMCID]
16. Roberts H, Hickey M. Managing the menopause: an update. Maturitas. 2016;86:53-8. [DOI:10.1016/j.maturitas.2016.01.007] [PMID]
17. Fondjo LA, Sakyi SA, Owiredu WKBA, Laing EF, Owiredu E-W, Awusi Er K, et al. Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis. Biomed Res Int. 2018:9369282. [DOI:10.1155/2018/9369282] [PMID] [PMCID]
18. Kanwar SNG, Shekhawat M, Sharma P, Hada R. Comparison of vitamin D levels in Pre and PostMenopausal Type 2 diabetic females. IOSR JDMS. 2015;14(8):70-73.
19. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, et al. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. Menopause. 2012;19(4):387-395. [DOI:10.1097/gme.0b013e31824d8f40] [PMID] [PMCID]
20. Bischoff-Ferrari HA, Borchers M, Gudat F, Dürmüller U, Stähelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265-9. [DOI:10.1359/jbmr.2004.19.2.265] [PMID]
21. Schmitt EB, Nahas-Neto J, Bueloni-Dias F, Poloni PF, Orsatti CL, Petri Nahas EA. Vitamin D deficiency is associated with metabolic syndrome in postmenopausal women. Maturitas. 2018;107:97-102. [DOI:10.1016/j.maturitas.2017.10.011] [PMID]
22. Fondjo LA, Owiredu WKBA, Sakyi SA, Laing EF, Adotey-Kwofie MA, Antoh EO, Detoh E. Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana. PLOS One. 2017;12(4):e0175388. [DOI:10.1371/journal.pone.0175388] [PMID] [PMCID]
23. Hantoosh HA, Mahdi MH, Imran BW, Yahya AA. Prevalence of vitamin D deficiency in Iraqi female at reproductive age. Med J Babylon. 2019;16(2):119-122. [DOI:10.4103/MJBL.MJBL_9_19]
24. Amini S, Jafarirad S, Amani R. Postpartum depression and vitamin D: A systematic review. Crit Rev Food Sci Nutr. 2019;59(9):1514-1520. [DOI:10.1080/10408398.2017.1423276] [PMID]
25. Cermisoni GC, Alteri A, Corti L, Rabellotti E, Papaleo E, Viganò P, et al. Vitamin D and endometrium: A systematic review of a neglected area of research. Int J Mol Sci. 2018;19(8):2320. [DOI:10.3390/ijms19082320] [PMID] [PMCID]
26. Al-Msaid HLF, AL-Sallami ASM. Study of Catsper1 protein levels in unexplained and idiopathic infertile men. The role of some biochemical markers and hormonal evidence in predisposition to osteoporosis in postmenopausal women. 2018;9(2):195-8. [DOI:10.25258/ijpqa.v9i2.13646]
27. Holick MF. The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153-65. [DOI:10.1007/s11154-017-9424-1] [PMID]
28. Mohammad S, Mishra A, Ashraf MZ. Emerging role of vitamin D and its associated molecules in pathways related to pathogenesis of thrombosis. Biomolecules. 2019;9(11):649. [DOI:10.3390/biom9110649] [PMID] [PMCID]
29. Halder SK, Osteen KG, Al-Hendy A. 1,25-Dihydroxyvitamin d3 reduces extracellular matrix-associated protein expression in human uterine fibroid cells. Biol Reprod. 2013;89(6):150. [DOI:10.1095/biolreprod.113.107714] [PMID] [PMCID]
30. Barbosa EM, Nonogaki S, Katayama ML, Folgueira MA, Alves VF, Brentani MM. Vitamin D3 modulation of plasminogen activator inhibitor type-1 in human breast carcinomas under organ culture. Virchows Arch. 2004;444(2):175-82. [DOI:10.1007/s00428-003-0929-5] [PMID]
31. Undas A, Ariëns RA. Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases. Arterioscler Thromb Vasc Biol. 2011;31(12):e88-99. [DOI:10.1161/ATVBAHA.111.230631]
32. Byrnes JR, Wolberg AS. Red blood cells in thrombosis. Blood. 2017;130(16):1795-1799. [DOI:10.1182/blood-2017-03-745349] [PMID] [PMCID]
33. Hammer Y, Soudry A, Levi A, Talmor-Barkan Y, Leshem-Lev D, Singer J, et al. Effect of vitamin D on endothelial progenitor cells function. PLOS One. 2017;12(5):e0178057. [DOI:10.1371/journal.pone.0178057] [PMID] [PMCID]
34. Gong ZH, Ji JF, Yang J, Xiang T, Zhou CK, Pan XL, et al. Association of plasminogen activator inhibitor-1 and vitamin D receptor expression with the risk of keloid disease in a Chinese population. Kaohsiung J Med Sci. 2017;33(1):24-29. [DOI:10.1016/j.kjms.2016.10.013] [PMID]
35. Badr Roomi A, Nori W, Mokram Hamed R. Lower Serum Irisin Levels Are Associated with Increased Osteoporosis and Oxidative Stress in Postmenopausal. Rep Biochem Mol Biol. 2021;10(1):13-19. [DOI:10.52547/rbmb.10.1.13] [PMID] [PMCID]
36. Rashid FA, Mahdi S, Mahdy SA, Salim AT. Effect of Obesity on Plasma Alkaline Phosphatase Activity in Breast Cancer. Rep Biochem Mol Biol. 2021;10(2):307-313. [DOI:10.52547/rbmb.10.2.307] [PMID] [PMCID]

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