Volume 11, Issue 3 (Vol.11 No.3 Oct 2022)                   rbmb.net 2022, 11(3): 377-385 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Beiramzadeh A, Heidari Z, Norozi M, Saravani M. Association Between HOTAIR rs920778 and H19 rs3741219 Polymorphisms with Hashimoto’s Thyroiditis (HT) and Graves’ Disease (GD). rbmb.net 2022; 11 (3) :377-385
URL: http://rbmb.net/article-1-908-en.html
Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran & Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan,Iran.
Abstract:   (1819 Views)
Background: Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) are two autoimmune thyroid diseases (AITDs). The current study aimed to assess possible association between HOTAIR rs920778 and H19 rs3741219 polymorphisms with GD and HT.
Methods: We recruited 248 patients with autoimmune thyroid disease (133 HT patients and 115 GD patients) and 135 age- and sex-matched controls. The PCR-RFLP method was applied for genotyping of HOTAIR rs920778, and H19 rs3741219 polymorphisms.
Results: The HOTAIR rs920778 GA frequency was significantly higher in control compared to HT group. The Overdominant model showed a significant association with the risk of HT. However, no significant association was observed between this polymorphism and HT susceptibility in dominant and recessive models. The H19 rs3741219 GA was more repeated in HT patients compared to control
group, but the difference was not significant. There was no association between HOTAIR rs920778 and H19 rs3741219 polymorphisms with GD in all genetic models.
Conclusions:Our findings indicated that HOTAIR rs920778 polymorphism decreased the risk of HT. Since, this the first study, further studies with different races are required to confirm our results.
Full-Text [PDF 218 kb]   (1030 Downloads)    
Type of Article: Original Article | Subject: Molecular Biology
Received: 2022/04/6 | Accepted: 2022/04/21 | Published: 2022/12/31

1. He W, Zhao J, Liu X, Li S, Mu K, Zhang J, et al. Associations between CD160 polymorphisms and autoimmune thyroid disease: a case-control study. 2021;21(1):148. [DOI:10.1186/s12902-021-00810-w] [PMID] [PMCID]
2. Liu X, Bai X, Zhao J, Gao C, Du P, Zhang J-a, et al. Associations between NLRC4 gene polymorphisms and autoimmune thyroid disease. Biomed Res Int. 2020;2020:1378427. [DOI:10.1155/2020/1378427] [PMID] [PMCID]
3. Li H-n, Li X-r, Du Y-y, Yang Z-f, Lv Z-tJFie. The association between Foxp3 polymorphisms and risk of Graves' disease: a systematic review and meta-analysis of observational studies. Front Endocrinol (Lausanne). 2020;11:392. [DOI:10.3389/fendo.2020.00392] [PMID] [PMCID]
4. He W, Wang B, Mu K, Zhang J, Yang Y, Yao W, et al. Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases. 2019;8(3):173-81. [DOI:10.1530/EC-18-0370] [PMID] [PMCID]
5. Shaker O, Mahfouz H, Salama A, Medhat E. Long Non-Coding HULC and miRNA-372 as Diagnostic Biomarkers in Hepatocellular Carcinoma patients. rbmb. 2020;9(2):230-240. [DOI:10.29252/rbmb.9.2.230] [PMID] [PMCID]
6. Yin L, Zeng C, Yao J, Shen JJE. Emerging roles for noncoding RNAs in autoimmune thyroid disease. Endocrinology. 2020;161(8):bqaa053. [DOI:10.1210/endocr/bqaa053] [PMID]
7. Wang J, Wei F, Zhou HJFiLM. Advances of lncRNA in autoimmune diseases. Frontiers in Laboratory Medicine. 2018;2(2):79-82. [DOI:10.1016/j.flm.2018.07.004]
8. Medhat E, Ayeldeen G, Hosni Ahmed H, Shaker O, Gheita T, Salama Ashour S. HOTAIR and THRIL Long Non Coding RNAs and Their Target Genes in Rheumatoid Arthritis patients. Rep Biochem Mol Biol. 2022;10(4):614-621. [DOI:10.52547/rbmb.10.4.697] [PMID] [PMCID]
9. Salimi S, Sargazi S, Heidari Nia M, Mirani Sargazi F, Ghasemi MJJoO, Research G. Genetic variants of HOTAIR are associated with susceptibility to recurrent spontaneous abortion: A preliminary case-control study. 2021;47(11):3767-3778. [DOI:10.1111/jog.14977] [PMID]
10. Hashemi M, Moazeni-Roodi A, Sarabandi S, Karami S, Ghavami SJJoG. Association between genetic polymorphisms of long noncoding RNA H19 and cancer risk: a meta-analysis. 2019;98:81. [DOI:10.1007/s12041-019-1126-x] [PMID]
11. Wang K, Zhu Z, Wang Y, Zong D, Xue P, Gu J, et al. The influence of LncRNA H19 polymorphic variants on susceptibility to cancer: A systematic review and updated meta-analysis of 28 case-control studies. PLoS One. 2021;16(7):e0254943. [DOI:10.1371/journal.pone.0254943] [PMID] [PMCID]
12. Xavier-Magalhães A, Oliveira AI, de Castro JV, Pojo M, Gonçalves CS, Lourenço T, et al. Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis. J Neurooncol. 2017;132(1):27-34. [DOI:10.1007/s11060-016-2345-0] [PMID]
13. Xia Z, Yan R, Duan F, Song C, Wang P, Wang K. Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated With Susceptibility to Breast Cancer in Chinese Population. Medicine (Baltimore). 2016;95(7):e2771. [DOI:10.1097/MD.0000000000002771] [PMID] [PMCID]
14. Song J, Kim D, Han J, Kim Y, Lee M, Jin E-JJC, et al. PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis. 2015;15(1):121-6. [DOI:10.1007/s10238-013-0271-4] [PMID]
15. Shaker OG, Mahmoud RH, Abdelaleem OO, Ahmed TI, Fouad NA, Hussein HA, et al. Expression profile of long noncoding RNAs, lnc-Cox2, and HOTAIR in rheumatoid arthritis patients. 2019;39(3):174-180. [DOI:10.1089/jir.2018.0117] [PMID]
16. Zhang X, Zhou L, Fu G, Sun F, Shi J, Wei J, et al. The identification of an ESCC susceptibility SNP rs920778 that regulates the expression of lncRNA HOTAIR via a novel intronic enhancer. 2014;35(9):2062-7. [DOI:10.1093/carcin/bgu103] [PMID]
17. Lv Z, Kou C, Chen N, Jia L, Sun X, Gao Y, et al. Single Nucleotide Polymorphisms in HOTAIR Are Related to Breast Cancer Risk and Prognosis in the Northeastern Chinese Population. 2021;11:706428. [DOI:10.3389/fonc.2021.706428] [PMID] [PMCID]
18. Li H, Tang X-M, Liu Y, Li W, Chen Q, Pan YJCP, et al. Association of functional genetic variants of HOTAIR with hepatocellular carcinoma (HCC) susceptibility in a Chinese population. 2017;44(2):447-454. [DOI:10.1159/000485011] [PMID]
19. Kim JO, Jun HH, Kim EJ, Lee JY, Park HS, Ryu CS, et al. Genetic variants of HOTAIR associated with colorectal cancer susceptibility and mortality. 2020;10:72. [DOI:10.3389/fonc.2020.00072] [PMID] [PMCID]
20. Qi Q, Wang J, Huang B, Chen A, Li G, Li X, et al. Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type. 2016;7(25):38775-38784. [DOI:10.18632/oncotarget.9608] [PMID] [PMCID]
21. Zhu H, Lv Z, An C, Shi M, Pan W, Zhou L, et al. Onco-lncRNA HOTAIR and its functional genetic variants in papillary thyroid carcinoma. Sci Rep. 2016;6:31969. [DOI:10.1038/srep31969] [PMID] [PMCID]
22. Huang A-F, Su L-C, Jia H, Liu Y, Xu W-DJCR. No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary Sjögren's syndrome in a Chinese Han population. Clin Rheumatol. 2017;36(11):2447-2453. [DOI:10.1007/s10067-017-3833-0] [PMID]
23. Chen X, Luo X, Wei Y, Sun H, Dai L, Tangzhou Y, et al. LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production. 2021;27(1):61. [DOI:10.1186/s10020-021-00326-y] [PMID] [PMCID]
24. Yang J, Li Y, Wang L, Zhang Z, Li Z, Jia QJB. LncRNA H19 aggravates TNF‐α‐induced inflammatory injury via TAK1 pathway in MH7A cells. Biofactors. 2020;46(5):813-820. [DOI:10.1002/biof.1659] [PMID]
25. Stuhlmüller B, Kunisch E, Franz J, Martinez-Gamboa L, Hernandez MM, Pruss A, et al. Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue. Am J Pathol. 2003;163(3):901-11. [DOI:10.1016/S0002-9440(10)63450-5] [PMID]
26. Wu J, Zhang T-P, Zhao Y-L, Li B-Z, Leng R- X, Pan H-F, et al. Decreased H19, GAS5, and linc0597 expression and association analysis of related gene polymorphisms in rheumatoid arthritis. 2019;10(1):55. [DOI:10.3390/biom10010055] [PMID] [PMCID]
27. Wang H, Li J, Cheng Y, Yao JJGT, Biomarkers M. Association of long-chain noncoding RNA H19 and MEG3 gene polymorphisms and their interaction with risk of osteoarthritis in a Chinese Han population. 2020;24(6):328-337. [DOI:10.1089/gtmb.2019.0230] [PMID]
28. Song Y, Xing H, Zhou L, Zhang N, Yang MJAot. LncRNA H19 modulated by miR-146b-3p/miR-1539-mediated allelic regulation in transarterial chemoembolization of hepatocellular carcinoma. 2021;95(9):3063-3070. [DOI:10.1007/s00204-021-03119-8] [PMID]
29. Zaaber I, Mestiri S, Marmouch H, Tensaout BBHJJAE. Polymorphisms in TSHR gene and the risk and prognosis of autoimmune thyroid disease in Tunisian population. 2020;16(1):1-8. [DOI:10.4183/aeb.2020.1] [PMID] [PMCID]
30. Heidari Z, Salimi S, Rokni M, Rezaei M, Khalafi N, Shahroudi MJ, et al. Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population. Biomed Res Int. 2021;2021:7729238. [DOI:10.1155/2021/7729238] [PMID] [PMCID]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2015 All Rights Reserved | Reports of Biochemistry and Molecular Biology

Designed & Developed by : Yektaweb