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Miresmaeili Mazrakhondi S A, Zare-Zardini H. Comparison of Serum Changes of Interleukin-17A and Interleukin-21 Between Schizophrenic Patients and Healthy Individuals. rbmb.net 2022; 11 (3) :465-470
URL: http://rbmb.net/article-1-939-en.html
Department of Biology, Faculty of Basic Science, Yazd University, Yazd, Iran.
Abstract:   (340 Views)
Background: Immunological alterations in schizophrenic patients have been considered during last decade. There are no remarkable reports on the changes of IL-17A and IL-21 in schizophrenic patients. Therefore, the purpose of this study was to evaluate changes of serum IL-17A and IL-21 in schizophrenic patients in comparison with healthy controls.

Methods: In the present study serum levels of IL-17A and IL-21 in 30 patients with schizophrenia before treatment and three months after treatment were measured by enzyme-linked immunosorbent assay (ELISA) and compare to 30 match healthy control group.

Results: Serum levels of IL-21 in schizophrenic patient was significantly higher than control group (P= 0.001). Serum levels of IL-17A in the schizophrenic patients had no significant changes than the control group (P= 0.4). Serum levels of IL-17A in patients with schizophrenia three months after treatment than before treatment had no significant change (P=0.7) and IL-21 serum levels in schizophrenic patient three month after treatment was not significant changed in comparison with this group before treatment (P= 0.06).

Conclusions: The serum levels of interlukine-21 is elevated in schizophrenic. Results of this study showed that IL-21 might be involved in the pathologic mechanism of schizophrenia.
Full-Text [PDF 205 kb]   (137 Downloads)    
Type of Article: Original Article | Subject: Biochemistry
Received: 2022/05/10 | Accepted: 2022/05/15 | Published: 2022/12/31

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