Reports of Biochemistry
and Molecular Biology
Mon, Dec 4, 2023
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Vol.12 No.2 Jul
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Atefeh Eivazi 
, Bahman Akbari , Sara Falahi , Ali Gorgin Karaji , Alireza Rezaiemanesh , Seyed Hamid Reza Mortazavi , Niloofar Daneshfar , Farhad Salari *
, Bahman Akbari , Sara Falahi , Ali Gorgin Karaji , Alireza Rezaiemanesh , Seyed Hamid Reza Mortazavi , Niloofar Daneshfar , Farhad Salari *
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract: (73 Views)
Background: Allergicrhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.
Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.
Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).
Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.
Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.
Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).
Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.
Keywords: Allergic rhinitis, Arachidonate 15-lipoxygenase, Immunoresolvents, Single-nucleotide polymorphism, Specialized proresolving lipid mediators (SPMs).
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