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Volume 12, Issue 3 (Vol.12 No.3 Oct 2023)
rbmb.net 2023, 12(3): 366-373 |
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Ananta Kahar L, Yusrawati Y, Jamsari J, Maskoen T, Aribowo K, Monika Sari W. The Role of Vitamin D Binding Protein and Vitamin D Level in Mortality of Sepsis Patients. rbmb.net 2023; 12 (3) :366-373
URL: http://rbmb.net/article-1-1213-en.html
URL: http://rbmb.net/article-1-1213-en.html
Liliriawati Ananta Kahar * 
, Yusrawati Yusrawati , Jamsari Jamsari , Tinni Maskoen , Kornelis Aribowo , Wiwi Monika Sari
, Yusrawati Yusrawati , Jamsari Jamsari , Tinni Maskoen , Kornelis Aribowo , Wiwi Monika Sari
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Andalas University, Dr. M. Djamil General Hospital, Padang, 25171, Indonesia.
Abstract: (634 Views)
Background: Vitamin D plays crucial roles in immune cell function, including macrophage activation, immune response modulation, and antimicrobial peptide production. Low vitamin D levels can result in reduced immune response, heightened inflammation, and impaired organ function, thereby exacerbating sepsis severity and impacting patient prognosis. This study investigates the influence of vitamin D binding protein expression and vitamin D levels on the mortality of septic patients.
Methods: This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises 40 patients in the case group and 40 patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method.
Results: Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below 200 µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< 0.05). Patients with vitamin D levels below 20 µg/mL faced a 2.54 times higher risk of mortality than those with levels exceeding 20 µg/mL.
Conclusions: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.
Methods: This analytical observational study employs a case-control approach and involves patients at the Critical Care Unit of Dr. M. Djamil General Hospital in Padang, Indonesia. The study comprises 40 patients in the case group and 40 patients in the control group. Vitamin D and vitamin D binding protein levels are assessed using the enzyme-linked immunosorbent assay method.
Results: Vitamin D and vitamin D binding protein levels were observed to be lower in the case group compared to the control group. In the case group, the majority of patients had vitamin D binding protein levels below 200 µg/mL. A significant association was found between vitamin D levels and mortality in sepsis patients (P< 0.05). Patients with vitamin D levels below 20 µg/mL faced a 2.54 times higher risk of mortality than those with levels exceeding 20 µg/mL.
Conclusions: Diminished levels of vitamin D binding protein and vitamin D contribute to an increased risk of mortality in septic patients.
Type of Article: Original Article |
Subject:
Molecular Biology
Received: 2023/07/25 | Accepted: 2023/09/15 | Published: 2024/02/25
Received: 2023/07/25 | Accepted: 2023/09/15 | Published: 2024/02/25
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