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Volume 13, Issue 2 (Vol.13 No.2 Jul 2024)
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Kareem Z R, Al-Kazazz F F, Rheima A M, Sultan A R. Evaluation of the Dysregulation of Cholesterol and Glucose Levels in Graves' Disease Using Clinical Data Analysis. rbmb.net 2024; 13 (2) :159-166
URL: http://rbmb.net/article-1-1400-en.html
URL: http://rbmb.net/article-1-1400-en.html
Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq.
Abstract: (589 Views)
Background: Graves’ disease (GD) is the most frequent reason for hyperthyroidism, which is brought on by an excess of thyroid hormone and a form of autoimmune thyroid disease (AITD). Patients with GD have higher levels of thyroid receptor antibody (TRAb). The current study, investigates the impact of excessive thyroid hormone production on glucose and cholesterol metabolism in thyroid disorders, particularly focusing on GD.
Methods: This study included 96 subjects (32 GD patients, 32 from non-autoimmune hyperthyroidism and 32 from healthy controls). All samples were obtained from Al-Kadhimiya Teaching Hospital (Baghdad) for the period between September 2023 and January 2024.
Results: The results revealed that mean± SD values of FT3 and FT4 for GD patients were significantly higher (P<0.001) accompanied by a significant decrease in mean±SD values of TSH (P<0.001) when compared to non-autoimmune hyperthyroidism and control groups. Conversely, TC and glucose levels did not show significant variations among GD patients, the non-immune hyperthyroidism and control groups (P > 0.05).
Conclusion: Our findings indicated thyroid function analysis is crucial for the diagnosis and differentiation of GD, TC and glucose levels do not contribute additional discriminatory power.
Methods: This study included 96 subjects (32 GD patients, 32 from non-autoimmune hyperthyroidism and 32 from healthy controls). All samples were obtained from Al-Kadhimiya Teaching Hospital (Baghdad) for the period between September 2023 and January 2024.
Results: The results revealed that mean± SD values of FT3 and FT4 for GD patients were significantly higher (P<0.001) accompanied by a significant decrease in mean±SD values of TSH (P<0.001) when compared to non-autoimmune hyperthyroidism and control groups. Conversely, TC and glucose levels did not show significant variations among GD patients, the non-immune hyperthyroidism and control groups (P > 0.05).
Conclusion: Our findings indicated thyroid function analysis is crucial for the diagnosis and differentiation of GD, TC and glucose levels do not contribute additional discriminatory power.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2024/05/25 | Accepted: 2024/08/19 | Published: 2025/01/4
Received: 2024/05/25 | Accepted: 2024/08/19 | Published: 2025/01/4
References
1. Cai L, Wang P, Xue C, Chen J, Zhang Y. Clinical Characteristics and Risk Factors Associated with Adverse Pregnancy Outcomes in Patients With Gestational Hypothyroidism: A Case-Control Study. Endocr Pract. 2024;30(2):101-106 [DOI:10.1016/j.eprac.2023.10.135] [PMID]
2. Hammodi NM, Al Aamery RA. Histological and immunohistochemical study of thyroid gland in Caucasian squirrel (Sciurus Anamalus) (Gmelin, 1778) by using marker (anti-thyroglobulin, code IR5090). Periodicals of Engineering and Natural Sciences (PEN). 2022;10(6):104. [DOI:10.21533/pen.v10i6.3383]
3. Keskin, A. Thyroid gland and vocational exposure to low dose ionizing radiation in health. Eurasian Journal of Medical and Biological Sciences. 2023; 3(2): 62-66.
4. Al-Kazazz, F. F., & AL-Bahadlii, M. M. Biochemical Study of Gonad Hormones in Sera of Iraqi Patients with Thyroid Disorder. Baghdad Science Journal. 2013; 10(3): 907-914. [DOI:10.21123/bsj.10.3.907-914]
5. Stojković, M. Thyroid function disorders. Archives of Pharmacy. 2022; 72(Notebook 5): 429-443. [DOI:10.5937/arhfarm72-39952]
6. Ogbonna SU, Ezeani IU. Risk Factors of Thyroid Dysfunction in Patients With Type 2 Diabetes Mellitus. Front Endocrinol (Lausanne). 2019;10:440. [DOI:10.3389/fendo.2019.00440] [PMID] []
7. Ogbonna SU, Ezeani IU, Okafor CI, Chinenye S. Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus. Diabetes Metab Syndr Obes. 2019;12:1113-1122. [DOI:10.2147/DMSO.S204836] [PMID] []
8. He J, Lai Y, Yang J, Yao Y, Li Y, Teng W, Shan Z. The Relationship Between Thyroid Function and Metabolic Syndrome and Its Components: A Cross-Sectional Study in a Chinese Population. Front Endocrinol (Lausanne). 2021;12:661160. [DOI:10.3389/fendo.2021.661160] [PMID] []
9. Beiramzadeh A, Heidari Z, Norouzi M, Saravani M. Association Between HOTAIR rs920778 and H19 rs3741219 Polymorphisms with Hashimoto's Thyroiditis (HT) and Graves' Disease (GD). Rep Biochem Mol Biol. 2022;11(3):377-385. [DOI:10.52547/rbmb.11.3.377] [PMID] []
10. Palella M, Giustolisi FM, Modica Fiascaro A, Fichera M, Palmieri A, Cannarella R, Calogero AE, Ferrante M, Fiore M. Risk and Prognosis of Thyroid Cancer in Patients with Graves' Disease: An Umbrella Review. Cancers (Basel). 2023;15(10):2724. [DOI:10.3390/cancers15102724] [PMID] []
11. Hsieh YS. Safety of Antithyroid Drugs in Avoiding Hyperglycemia or Hypoglycemia in Patients With Graves' Disease and Type 2 Diabetes Mellitus: A Literature Review. Cureus. 2023;15(6):e41017. [DOI:10.7759/cureus.41017]
12. Khinteel Jabbar N, Al-Abady ZN, Jasib Thaaban Almzail A, Al-Athary RAH. Relationship between Menopause and Complications of Hyperthyroidism in Female Patients in Iraq. Arch Razi Inst. 2022;77(4):1481-1489.
13. Abbood AH, Majeed Hameed R, Ghazi Al Safi W. Neuregulin 4 in Polycystic Ovarian Syndrome (PCOS) Phenotypes: A Key Role or Standby. Rep Biochem Mol Biol. 2023;12(3):359-365.
14. Mohammed, N, Aldeen, B, Asmeil, S. A study on the prevalence of thyroid disorders among males and females in EL-Beida City Libya. Int J Multidiscip Sci Adv Technol, . 2021;1:328-33.
15. Santin AP, Furlanetto TW. Role of estrogen in thyroid function and growth regulation. J Thyroid Res. 2011;2011:875125. [DOI:10.4061/2011/875125] [PMID] []
16. Yang Q, Kennicott K, Zhu R, Kim J, Wakefield H, Studener K, Liang Y. Sex hormone influence on female-biased autoimmune diseases hints at puberty as an important factor in pathogenesis. Front Pediatr. 2023 ;11:1051624. [DOI:10.3389/fped.2023.1051624] [PMID] []
17. Al-Saadi, MA, Nadhaif, ET, & AL-Jibouri, SA. The Relation Between Thyroid Function and Auto-Antibodies in Graves' Disease and Non-Autoimmune Hyperthyroidism Disease in AL-Najaf Province. Kufa Journal for Nursing Sciences. 2015; 5(3), 10-21. [DOI:10.36321/kjns.vi20153.2743]
18. Ali, AJM, Hamoud, MJM. Assessment of the Correlation Between Vitamin D and T3, T4, FT3, FT4 and TSH Among Patients with Graves' Disease. Pakistan Journal of Medical & Health Sciences. 2022; 16(05), 1500-1500. [DOI:10.53350/pjmhs221651500]
19. Malmstroem S, Grove-Laugesen D, Riis AL, Bruun BJ, Ebbehoj E, Hansen KW, Watt T, Rejnmark L. Muscle Performance and Postural Stability Are Reduced in Patients with Newly Diagnosed Graves' Disease. Thyroid. 2019;29(6):783-789. [DOI:10.1089/thy.2018.0318] [PMID]
20. Al-Jabery QA, Hatem RM. Measurement of TPO Ab and TG Ab levels and its association with thyroid dysfunction in Graves' disease patients in Najaf city: Graves' disease. Al-Kufa University Journal for Biology. 2023; 15(2), 67-72. [DOI:10.36320/ajb/v15.i2.12125]
21. Dong F, Li L, Bian Y, Li G, Han X, Li M, Liu J, Xue Y, Li Y, Hu Y, Tan J. Standardized Uptake Value Using Thyroid Quantitative SPECT/CT for the Diagnosis and Evaluation of Graves' Disease: A Prospective Multicenter Study. Biomed Res Int. 2019;2019:7589853. [DOI:10.1155/2019/7589853] [PMID] []
22. Zhang Y, Wang Y, Liu M, Wei L, Huang J, Dong Z, Guan M, Wu W, Gao J, Huang X, Guo X, Xie P. The value of FT4/TSH ratio in the differential diagnosis of Graves' disease and subacute thyroiditis. Front Endocrinol (Lausanne). 2023;14:1148174. [DOI:10.3389/fendo.2023.1148174] [PMID] []
23. Sulu C, Dedeoglu SE, Gonen B, Hepokur M, Guzel AN, Sahin S, Demir AN, Kara Z, Konukoglu D, Damci T, Gonen MS. Serum Lipoprotein(a) Is Not Associated with Graves' Ophthalmopathy. Metab Syndr Relat Disord. 2024;22(1):69-76. [DOI:10.1089/met.2023.0162] [PMID]
24. Lee HY, Sim BC, Nga HT, Moon JS, Tian J, Linh NT, Ju SH, Choi DW, Setoyama D, Yi HS. Metabolite Changes during the Transition from Hyperthyroidism to Euthyroidism in Patients with Graves' Disease. Endocrinol Metab (Seoul). 2022;37(6):891-900. [DOI:10.3803/EnM.2022.1590] [PMID] []
25. Xia Q, Qian W, Chen L, Chen X, Xie R, Zhang D, Wu H, Sun H, Wang F, Liu J, Chen T. Comprehensive Metabolomics Study in Children With Graves' Disease. Front Endocrinol (Lausanne). 2021;12:752496. [DOI:10.3389/fendo.2021.752496] [PMID] []
26. Song E, Koo MJ, Noh E, Hwang SY, Park MJ, Kim JA, Roh E, Choi KM, Baik SH, Cho GJ, Yoo HJ. Risk of Diabetes in Patients with Long-Standing Graves' Disease: A Longitudinal Study. Endocrinol Metab (Seoul). 2021;36(6):1277-1286. [DOI:10.3803/EnM.2021.1251] [PMID] []
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