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Jawad Kadhim A, Dhafir El-Yaseen H, Mohammed Jawad A. Correlation of Klotho Protein with Troponin-I as a Marker of Myocardial Damage in Iraqi Beta-Thalassemia Major Patients. rbmb.net 2024; 13 (2) :154-158
URL: http://rbmb.net/article-1-1404-en.html
URL: http://rbmb.net/article-1-1404-en.html
Department of Biochemistry, College of Medicine, University of Baghdad, Baghdad-Iraq.
Abstract: (671 Views)
Background: Beta thalassemia is a hereditary blood condition characterized by a decrease or absence in the production of the beta-globin chain of hemoglobin. Patients with beta-thalassemia major often require regular blood transfusions and are at an increased risk of developing complications such as iron overload and cardiac injury. In recent years, there has been increasing interest in Klotho protein as a multifunctional protein known for its anti-aging and cardio-protective properties. Several studies have revealed a potential correlation between Troponin, a protein released into the circulation as a result of heart muscle damage, and the level of Klotho protein.
Methods: This study included thirty Beta-Thalassemia Major (β-TM) patients and thirty control healthy subjects. Levels of Klotho protein and Troponin-I were determined using the ELISA technique and measured for all participants.
Results: Serum Klotho protein and Troponin-I levels were significantly elevated in β-TM patients compared to healthy control subjects (P< 0.001). A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients’ group.
Conclusion: A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients, which may highlight a relationship between Klotho and cardiac damage.
Methods: This study included thirty Beta-Thalassemia Major (β-TM) patients and thirty control healthy subjects. Levels of Klotho protein and Troponin-I were determined using the ELISA technique and measured for all participants.
Results: Serum Klotho protein and Troponin-I levels were significantly elevated in β-TM patients compared to healthy control subjects (P< 0.001). A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients’ group.
Conclusion: A positive correlation was found between serum Klotho protein and Troponin-I in the β-TM patients, which may highlight a relationship between Klotho and cardiac damage.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2024/05/31 | Accepted: 2024/07/22 | Published: 2025/01/4
Received: 2024/05/31 | Accepted: 2024/07/22 | Published: 2025/01/4
References
1. Faraj SA. Hemostatic parameters in Thalassemia patients; a single institute experience. J Fac Med Baghdad. 2016;58(2):132-5. [DOI:10.32007/jfacmedbagdad.582223]
2. Harbi NS, Jawad AH, Alsalman FK. Evaluation of Adipokines Concentration in Iraqi Patients with Major and Minor Beta Thalassemia. Reports Biochem Mol Biol. 2020;9(2):209-15. [DOI:10.29252/rbmb.9.2.209] [PMID] []
3. Akiki N, Hodroj MH, Bou-Fakhredin R, Matli K, Taher AT. Cardiovascular Complications in β-Thalassemia: Getting to the Heart of It. Thalass Reports 2023, Vol 13, Pages 38-50. 2023 Jan 30;13(1):38-50. [DOI:10.3390/thalassrep13010005]
4. Junho CVC, González-Lafuente L, Neres-Santos RS, Navarro-García JA, Rodríguez-Sánchez E, Ruiz-Hurtado G, et al. Klotho relieves inflammation and exerts a cardioprotective effect during renal ischemia/reperfusion-induced cardiorenal syndrome. Biomed Pharmacother. 2022 Sep 1;153:113515. [DOI:10.1016/j.biopha.2022.113515] [PMID]
5. Tyurenkov IN, Perfilova VN, Nesterova AA, Glinka Y. Klotho Protein and Cardio-Vascular System. Biochem. 2021;86(2):132-45. [DOI:10.1134/S0006297921020024] [PMID]
6. Ibrahim AE, EL-Yassin HD, AL-Janabi HK. The impact of inflammation on Resistin, Insulin and Troponin I in Acute Myocardial Infarction patients. J Fac Med Baghdad. 2011;53(3):338-42.
https://doi.org/10.32007/jfacmedbagdad.523989 [DOI:10.32007/jfacmedbagdad.533843]
7. Giordano S, Estes R, Li W, George R, Gilford T, Glasgow K, et al. Troponin Structure and Function in Health and Disease. Am Soc Clin Lab Sci. 2018 Oct 1;31(4):192-9. [DOI:10.29074/ascls.2018000679]
8. Harbi NS, Jawad AH, Alsalman FK. Evaluation of Adipokines Concentration in Iraqi Patients with Major and Minor Beta Thalassemia. Reports Biochem Mol Biol. 2020;9(2):209-15. [DOI:10.29252/rbmb.9.2.209] [PMID] []
9. Mettananda S, Pathiraja H, Peiris R, Wickramarathne N, Bandara D, de Silva U, et al. Blood transfusion therapy for β-thalassemia major and hemoglobin E β-thalassemia: Adequacy, trends, and determinants in Sri Lanka. Pediatr Blood Cancer. 2019 May 1;66(5). [DOI:10.1002/pbc.27643] [PMID]
10. Hammod H, Mokif TA, Al-Harbi HJ. The correlation between thalassemia with body mass index and blood groups in children and adult patient in the province of babylon, iraq. Asian J Pharm Clin Res. 2018;11(9):509-12. [DOI:10.22159/ajpcr.2018.v11i9.27100]
11. Maes M, Moustafa SR, Al-Hakeim HK, Alhillawi ZH. In Transfusion-dependent Thalassemia, Increased Iron Overload is Associated with Lower Serum Alpha-klotho, Which is Strongly Associated with Lower Total and Ionized Calcium Concentrations. 2020;(July):1-31. [DOI:10.20944/preprints202007.0347.v1]
12. Su XM, Yang W. α-Klotho is an acute phase protein and altered by restraint stress in mice. Int J Clin Exp Pathol. 2014;7(9):5922.
13. Olejnik A, Krzywonos-Zawadzka A, Banaszkiewicz M, Bil-Lula I. Klotho Protein Decreases MMP-Mediated Degradation of Contractile Proteins during Ischaemia/Reperfusion Injury to the Cardiomyocytes. Int J Mol Sci. 2022;23(24). [DOI:10.3390/ijms232415450] [PMID] []
14. ibrahim A jaber, AL-Saeed AHM. Evaluation of some heart enzymes and Iron levels in β-thalassemia patients in Thi-Qar City, Iraq. Baghdad Sci J. 2024 Jun 1;21(6):2007-2007. [DOI:10.21123/bsj.2023.8352]
15. Shahramian I, Razzaghian M, Ramazani AA, Ahmadi GA, Noori NM, Rezaee AR. The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia. Int Cardiovasc Res J. 2013 Jun;7(2):51.
16. Barbero U, Ajassa M, Gaglioti CM, Piga A, Ferrero GB, Longo F. The influence of cardiovascular risk factors and hypogonadism on cardiac outcomes in an aging population of beta-thalassemia patients. J Cardiovasc Dev Dis. 2022 Jan 1;9(1). [DOI:10.3390/jcdd9010003] [PMID] []
17. Lanzani C, Citterio L, Vezzoli G. Klotho: A link between cardiovascular and non-cardiovascular mortality. Clin Kidney J. 2020;13(6):926-32. [DOI:10.1093/ckj/sfaa100] [PMID] []
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