Volume 2, Issue 2 (Vol.2 No.2 Apr 2014)                   rbmb.net 2014, 2(2): 98-102 | Back to browse issues page

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Ebrahimzadeh-Vesal R, Azam R, Ghazarian A, Hajesmaeili M, Ranji N, Ezzati M R, et al . Recurrent Pregnancy Loss in a Subject with Heterozygote Factor V Leiden Mutation; a Case Report. rbmb.net. 2014; 2 (2) :98-102
URL: http://rbmb.net/article-1-50-en.html
Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (5774 Views)

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is considered as a significant risk factor for recurrent pregnancy loss. The inherited predisposition to thrombophilia is most often associated with factor V Leiden mutation, prothrombin G20210A mutation, and methylenetetrahydrofolate reductase C677T and A1298C gene variants. The net effect is an increased cleavage of prothrombin to thrombin and excessive blood coagulation.

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Subject: Biochemistry
Received: 2013/08/12 | Accepted: 2013/11/7 | Published: 2014/04/30

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