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Ansari-Moghaddam B, Kiani A A, Sheikhian A, Birjandi M, Ahmadi S A Y, Mousavi N, et al . Rheumatoid arthritis is associated with KIR2DS4-full among the KIR genes in Lur Population of Iran. rbmb.net. 2021; 10 (1) :84-94
URL: http://rbmb.net/article-1-610-en.html
Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract:   (820 Views)
Background: The pathophysiology underlying the progression and development of autoimmune conditions, such as Rheumatoid Arthritis (RA), is a result of dysregulations of the immune system. Research has explored the genetic alterations present in RA; however, limited studies have examined the role of Killer cell Immunoglobulin-like Receptors (KIR) and Human Leukocyte Antigen (HLA) molecules in RA. Therefore, the aim of this study was to examine KIR genes, their HLA ligands, and KIR-HLA compounds in patients with RA.

Methods: In this case-control study, a total of 50 patients with RA and 100 healthy individuals were enrolled. DNA samples were evaluated using PCR with sequence specific Primers (PCR-SSP). Odds ratio (OR) with a 95% confidence interval (CI) were reported.

Results: Among the KIR genes examined, KIR2DLA (p= 0.0255, OR= 0.389, 95% CI= 0.210-0.722) and KIR2DS4-full (p< 0.0001, OR= 6.163, 95% CI= 3.174-11.968) were observed to have a statistically significant correlation with disease susceptibility to RA. As an inhibitory gene, KIR2DLA was observed to have a protective effect against RA while KIR2DS4-full as an activating gene, was found to increase risk for RA. No significant associations were found between any of the other KIR genotypes, HLA ligands, or KIR-HLA compounds examined in this study to RA susceptibility.

Conclusions: In this study of RA in the Lur population of Iran, KIR2DS4-full was observed to increase susceptibility to RA, while KIR2DL5A was found to act as a protecting factor based on both the cross Table and regression analyses. Further research should focus on repeating this study in additional populations.
Full-Text [PDF 451 kb]   (304 Downloads)    
Type of Article: Original Article | Subject: Immunology
Received: 2020/11/21 | Accepted: 2020/12/13 | Published: 2021/05/9

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