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Shawky S A, Gaber O, Mostafa E, Sarhan W M. Uncoupling Protein 2 Expression Modulates Obesity in Chronic Kidney Disease Patients. rbmb.net. 2021; 10 (1) :119-125
URL: http://rbmb.net/article-1-639-en.html
Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Abstract:   (505 Views)
Background: Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients.

Methods: UCP2 gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in 93 participants divided into three groups. The groups included 31 non-obese CKD patients, 31 obese CKD patients, and 31 healthy, age-matched, unrelated volunteers as a control group.

Results: UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0.001). No significant association was found when the groups were compared by gender; Chi-square (X2) was 2.38 and p= 0.304. A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0.05).

Conclusions: These results indicate that UCP2 gene expression plays a significant role as a risk factor for obesity in CKD patients.
Full-Text [PDF 273 kb]   (169 Downloads)    
Type of Article: Original Article | Subject: Molecular Biology
Received: 2021/01/13 | Accepted: 2021/02/8 | Published: 2021/05/9

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