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Clinical laboratory sciences Department, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia & Medical Biochemistry Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Abstract:   (53 Views)
Background: Epilepsy is one of the most widespread neurological disease worldwide. Status epilepticus (SE) is a life-threatening neurologic disorder. Neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. This study aimed to assess the impact of berberine on some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy.

Methods: This work was performed on; Group I: (control), Group II: berberine‐treated control, Group III: epilepsy group, Group IV: berberine‐treated epilepsy. Groups were subjected to assessment of Tumor growth factor-1ꞵ (TGF-1ꞵ), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing factor (NRSF) gene expression.

Results: Study showed significant increase in levels of HIF-1α, TGF-1β, HDAC activity & NRSF gene expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. Significant decrease in BDNF levels in epilepsy & elevation in them in berberine treated epilepsy group.
Conclusions: Our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors & inflammatory biomarkers in a mice model of epilepsy. 
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Type of Article: Original Article | Subject: Biochemistry
Received: 2021/02/20 | Accepted: 2021/03/15

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