Reports of Biochemistry
and Molecular Biology
Thu, Apr 18, 2024
[Archive]
Volume 10, Issue 2 (Vol.10 No.2 Jul 2021)
rbmb.net 2021, 10(2): 307-313 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Aqeel Rashid F, Mahdi S, Abd-alkader Mahdy S, Thamer Salim A. Effect of Obesity on Plasma Alkaline Phosphatase Activity in Breast Cancer. rbmb.net 2021; 10 (2) :307-313
URL: http://rbmb.net/article-1-663-en.html
URL: http://rbmb.net/article-1-663-en.html
Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
Abstract: (2779 Views)
Background: Breast cancer is most common cancer in women. Obesity is one of related-risk factor in breast cancer. In obese normal subjects, alkaline phosphatase (ALP) has been studied. However, there is no previous study investigate the association between ALP and obesity in breast cancer and its correlation with other clinical characteristics. Therefore, the objective of present study is to investigate the association between ALP and clinical characteristics in generally and obesity in particularly.
Methods: A cross-study 111 new diagnosed breast cancer patients was included. Plasma ALP was measured in different subgroups: patients age <40 vs >40, premenopausal vs postmenopausal, estrogen receptor-positive (ER+) vs estrogen receptor negative (ER-), metastasis vs non-metastasis and obese vs non-obese patients.
Results: Significant increasing on plasma ALP were shown between groups of each age, menopausal status, metastasis, and obesity (p< 0.05, p< 0.05, p< 0.01 and p< 0.05) respectively. Positive correlation was observed between plasma ALP and age, menopausal status, metastasis, and obesity (r: 0.616, p< 0.05; r: 0.667, p< 0.01; r: 0.691, p< 0.005; and r: 0.627, p< 0.01). Multiple regression analysis was indicated that ALP can be determined by menopausal status, metastasis, and obesity (β-Coefficient = 0.428, p< 0.01; β-Coefficient = 0.534; p< 0.001; β-coefficient= 0.545; p= 0.005), respectively.
Conclusions: Together, the relation between ALP and obesity indicates that ALP could have a role in maturation of preadipocytes of breast cancer patients. Further investigations are needed to confirm that there could be a potential hormonal link between ALP and obesity in breast cancer patients.
Methods: A cross-study 111 new diagnosed breast cancer patients was included. Plasma ALP was measured in different subgroups: patients age <40 vs >40, premenopausal vs postmenopausal, estrogen receptor-positive (ER+) vs estrogen receptor negative (ER-), metastasis vs non-metastasis and obese vs non-obese patients.
Results: Significant increasing on plasma ALP were shown between groups of each age, menopausal status, metastasis, and obesity (p< 0.05, p< 0.05, p< 0.01 and p< 0.05) respectively. Positive correlation was observed between plasma ALP and age, menopausal status, metastasis, and obesity (r: 0.616, p< 0.05; r: 0.667, p< 0.01; r: 0.691, p< 0.005; and r: 0.627, p< 0.01). Multiple regression analysis was indicated that ALP can be determined by menopausal status, metastasis, and obesity (β-Coefficient = 0.428, p< 0.01; β-Coefficient = 0.534; p< 0.001; β-coefficient= 0.545; p= 0.005), respectively.
Conclusions: Together, the relation between ALP and obesity indicates that ALP could have a role in maturation of preadipocytes of breast cancer patients. Further investigations are needed to confirm that there could be a potential hormonal link between ALP and obesity in breast cancer patients.
Type of Article: Original Article |
Subject:
Biochemistry
Received: 2021/02/25 | Accepted: 2021/04/18 | Published: 2021/08/26
Received: 2021/02/25 | Accepted: 2021/04/18 | Published: 2021/08/26
References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Hashim MJ, Fatima AA-S, Noura AA-M, Sarah SA-Q, Ali HM, Gulfaraz K. Burden of Breast Cancer in the Arab World: Findings from Global Burden of Disease, 2016. J Epidemiol Glob Health. 2018;8(1-2):54-58. [DOI:10.2991/j.jegh.2018.09.003] [PMID] [PMCID]
3. Kulhánová I, Bray F, Fadhil I, Al-Zahrani AS, El-Basmy A, Anwar WA, et al. Profile of cancer in the Eastern Mediterranean region: The need for action. Cancer Epidemiol. 2017;47:125-132. [DOI:10.1016/j.canep.2017.01.009] [PMID]
4. Annual Statistical Report 2016. Planning Directorate, Ministry of Health /Environment, Republic of Iraq, 2017.
5. Annual Report of Cancer Diseases, Iraqi Cancer Registry 2013. Republic of Iraq: Iraqi Cancer Board, Ministry of Health, Iraq, 2017.
6. Munsell MF, Sprague BL, Berry DA, Chisholm G, Trentham-Dietz A. Body mass index and breast cancer risk according to postmenopausal estrogen-progestin use and hormone receptor status. Epidemiol Rev. 2014;36(1):114-36. [DOI:10.1093/epirev/mxt010] [PMID] [PMCID]
7. Gravena AAF, Romeiro Lopes TC, Demitto MdO, Borghesan DHP, Dell' Agnolo CM, Brischiliari SCR, et al. The Obesity and the Risk of Breast Cancer among Pre and Postmenopausal Women. Asian Pac J Cancer Prev. 2018;19(9):2429-2436.
8. Kershaw EE, Flier JS. Adipose Tissue as an Endocrine Organ. J Clin Endocrinol Metab. 2004;89(6):2548-56. [DOI:10.1210/jc.2004-0395] [PMID]
9. Weiss MJ, Henthorn PS, Lafferty MA, Slaughter C, Raducha M, Harris H. Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline phosphatase. Proc Natl Acad Sci U S A. 1986;83(19):7182-7186. [DOI:10.1073/pnas.83.19.7182] [PMID] [PMCID]
10. Berger J, Garattini E, Hua JC, Udenfriend S. Cloning and sequencing of human intestinal alkaline phosphatase cDNA. Proc Natl Acad Sci U S A. 1987;84(3):695-698. [DOI:10.1073/pnas.84.3.695] [PMID] [PMCID]
11. Millán JL. Oncodevelopmental expression and structure of alkaline phosphatase genes. Anticancer Res. 1988;8(5a):995-1004.
12. Ali AT, Penny CB, Paiker JE, Psaras G, Ikram F, Crowther NJ. The effect of alkaline phosphatase inhibitors on intracellular lipid accumulation in preadipocytes isolated from human mammary tissue. Ann Clin Biochem. 2006;43(Pt 3):207-13. [DOI:10.1258/000456306776865179] [PMID]
13. Ali AT, Penny CB, Paiker JE, van Niekerk C, Smit A, Ferris WF, et al. Alkaline phosphatase is involved in the control of adipogenesis in the murine preadipocyte cell line, 3T3-L1. Clin Chim Acta. 2005;354(1-2):101-9. [DOI:10.1016/j.cccn.2004.11.026] [PMID]
14. Ali AT, Ferris WF, Penny CB, Van der Merwe MT, Jacobson BF, Paiker JE, et al. Lipid accumulation and alkaline phosphatase activity in human preadipocytes isolated from different body fat depots. Journal of Endocrinology, Metabolism and Diabetes of South Africa. 2013;18(1):58-64. [DOI:10.1080/22201009.2013.10872304]
15. Ahmadiankia N, Bagheri M, Fazli M. Gene Expression Changes in Pomegranate Peel Extract-Treated Triple-Negative Breast Cancer Cells. Rep Biochem Mol Biol. 2018;7(1):102-109.
16. Raghunathachar Sahana K, Akila P, Prashant V, Sharath Chandra B, Nataraj Suma M. Quantitation of Vascular Endothelial Growth Factor and Interleukin-6 in Different Stages of Breast Cancer. Rep Biochem Mol Biol. 2017;6(1):33-39.
17. Ali AT, Paiker JE, Crowther NJ. The Relationship Between Anthropometry and Serum Concentrations of Alkaline Phosphatase Isoenzymes, Liver Enzymes, Albumin, and Bilirubin. Am J Clin Pathol. 2006;126(3):437-42. [DOI:10.1309/9N346GXX67B6PX5W] [PMID]
18. Huang P, Lan M, Peng AF, Yu QF, Chen WZ, Liu ZL, et al. Serum calcium, alkaline phosphotase and hemoglobin as risk factors for bone metastases in bladder cancer. PLoS One. 2017;12(9):e0183835. [DOI:10.1371/journal.pone.0183835] [PMID] [PMCID]
19. Yazdani A, Dorri S, Atashi A, Shirafkan H, Zabolinezhad H. Bone Metastasis Prognostic Factors in Breast Cancer. Breast Cancer (Auckl). 2019;13:1178223419830978. [DOI:10.1177/1178223419830978] [PMID] [PMCID]
20. Schiele F, Henny J, Hitz J, Petitclerc C, Gueguen R, Siest G. Total bone and liver alkaline phosphatases in plasma: biological variations and reference limits. Clin Chem. 1983;29(4):634-41. [DOI:10.1093/clinchem/29.4.634] [PMID]
21. Crilly RG, Jones MM, Horsman A, Nordin BE. Rise in plasma alkaline phosphatase at the menopause. Clin Sci (Lond). 1980;58(4):341-2. [DOI:10.1042/cs0580341] [PMID]
22. Chen WZ, Shen JF, Zhou Y, Chen XY, Liu JM, Liu ZL. Clinical characteristics and risk factors for developing bone metastases in patients with breast cancer. Sci Rep. 2017;7(1):11325. [DOI:10.1038/s41598-017-11700-4] [PMID] [PMCID]
23. Munan L, Kelly A, PetitClerc C, Billon B. Associations with body weight of selected chemical constituents in blood: epidemiologic data. Clin Chem. 1978;24(5):772-7. [DOI:10.1093/clinchem/24.5.772] [PMID]
24. Pardhe BD, Pathak S, Bhetwal A, Ghimire S, Shakya S, Khanal PR, et al. Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal. Int J Womens Health. 2017;9:781-788. [DOI:10.2147/IJWH.S145191] [PMID] [PMCID]
25. Rashid FA. Alhashemi WKH, Al-Saffar AT, Salman EA, Najeeb DA. Obesity and breast cancer risk in different menopausal status: a review. Biochem Cell Arch. 2020;20(1):1875-1878.
26. Fortner RT, Katzke V, Kühn T, Kaaks R. Obesity and Breast Cancer. Recent Results Cancer Res. 2016; 208:43-65. [DOI:10.1007/978-3-319-42542-9_3] [PMID]
27. Holzer G, Einhorn TA, Majeska RJ. Estrogen regulation of growth and alkaline phosphatase expression by cultured human bone marrow stromal cells. J Orthop Res. 2002;20(2):281-8. [DOI:10.1016/S0736-0266(01)00092-4]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
