Volume 10, Issue 4 (Vol.10 No.4 Jan 2022)                   rbmb.net 2022, 10(4): 573-579 | Back to browse issues page


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Savira M, Suhaimi D, Putra A E, Yusrawati Y, Lipoeto N I. Prevalence Oncogenic Human Papillomavirus in Cervical Cancer Patients in Riau Province Indonesia. rbmb.net. 2022; 10 (4) :573-579
URL: http://rbmb.net/article-1-672-en.html
Faculty of Medicine, Andalas University, Padang, West Sumatera, Indonesia & Microbiology Department, Faculty of Medicine, Universitas Riau, Pekanbaru, Riau, Indonesia.
Abstract:   (1000 Views)
Background: Cervical cancer is the fourth most deadly cancer in the world, and it is caused by infection of high-risk subtypes of Human PapillomaVirus (HPV) in most cases. The aims of this study were to determine the prevalence oncogenic HPV in cervical cancer patients in Riau Province Indonesia and to determine the clinical manifestation of HPV in cervical cancer patients in Riau Province Indonesia.

Methods: This research was a descriptive study conducted at Arifin Achmad General Hospital Riau from February to August 2018 which aimed to analyze HPV genotype prevalence oncogenic of cervical cancer patients.

Results: This study showed out 86 of 110 women (78.1%) were found HPV positive, and the most common genotype of HPV was HPV 16 (38.2%). The average age of cervical cancer patient was 50 years old, and the average number of parities was 4 times. The majority of participants were married at the age before 20 years (77.3%) and had low educational background (64.5%). Vaginal bleeding happened in more than half of the participant as major clinical manifestation (72.7%), followed by fluor albus (72.7%), pelvic pain (60.2%) and fatigue (65.9%).

Conclusions: The most common HPV genotype in Riau Province was HPV type 16 and the most common clinical symptoms of cervical cancer patient were vaginal bleeding, fluor albus, pelvic pain and fatigue.
Full-Text [PDF 269 kb]   (488 Downloads)    
Type of Article: Original Article | Subject: Molecular Biology
Received: 2021/03/16 | Accepted: 2021/04/18 | Published: 2022/02/7

References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. [DOI:10.3322/caac.21492] [PMID]
2. Manga MM, Fowotade A, Abdullahi YM, El-Nafaty AU, Adamu DB, Pindiga HU, et al. Epidemiological patterns of cervical human papillomavirus infection among women presenting for cervical cancer screening in North-Eastern Nigeria. Infect Agent Cancer. 2015;10:39. [DOI:10.1186/s13027-015-0035-8] [PMID] [PMCID]
3. Nurcahyanti AD. Cervical Cancer: The Case in Indonesia and Natural Product- Based Therapy. J Cancer Biol Res. 2016;4(1):1078.
4. Rezai M, Saravani R, Sargazi S, Moudi M, Jafari Shahroudi M, Saravani R. Achillea Wilhelmsii C. Koch Hydroalcoholic Extract Induces Apoptosis and Alters LIN28B and p53 Gene Expression in Hela Cervical Cancer Cells. Rep Biochem Mol Biol. 2019;8(3):318-325.
5. Wang KL Human Papillomavirus and Vaccination in Cervical Cancer. Taiwan J Obstet Gynecol. 2007;46(4): 352-362. [DOI:10.1016/S1028-4559(08)60004-2]
6. Bruni L, Barrionuevo-Rosas L, Serrano B, Gomez D, Munoz J, Bosch F, et al. Human papillomavirus and Related diseases report in Indonesia. ICO Inf Cent HPV Cancer. 2017.
7. Pan J, Kavanagh K, Cuschieri K, Pollock KG, Gilbert DC, Millan D, et al. Increased risk of HPV-associated genital cancers in men and women as a consequence of pre-invasive disease. Int J Cancer. 2019;145(2):427-434. [DOI:10.1002/ijc.32126] [PMID]
8. Kovacevic G, Milosevic V, Knezevic P, Knezevic A, Knezevic I, Radovanov J, et al. Prevalence of oncogenic Human papillomavirus and genetic diversity in the L1 gene of HPV16 HPV 18 HPV31 and HPV33 found in women from Vojvodina Province Serbia. Biologicals. 2019;58:57-63. [DOI:10.1016/j.biologicals.2019.02.001] [PMID]
9. Lipinwati. Molecular Diagnosis of Human Papilloma Virus (HPV) Causes Cervical Cancer Lipinwati. Jambi Med J. 2014;2(1):78-86.
10. Chiang YC, Chen YY, Hsieh SF, Chiang CJ, You SL, Cheng WF, et al. Screening frequency and histologic type influence the efficacy of cervical cancer screening: A nationwide cohort study. Taiwan J Obstet Gynecol. 2017;56(4):442-448. [DOI:10.1016/j.tjog.2017.01.010] [PMID]
11. Stapley S, Hamilton W. Gynaecological symptoms reported by young women: examining the potential for earlier diagnosis of cervical cancer. Family Practice. 2011;28(6):592-598. [DOI:10.1093/fampra/cmr033] [PMID]
12. Mongan SP, Andrijono Andrijono, Tjahadi H. Obstet Gynecol Human Papilloma Virus L1 Gene Methylation as a Potential Biomarker for Precancerous Cervical Lesion: a Preliminary Report Human Papilloma Virus L1 Gene Methylation as a Potential Biomarker for Precancerous Cervical Lesions: A Preliminary Report. Indones Obstet Gynecol 2017;5-2. 120-126. [DOI:10.32771/inajog.v5i2.532]
13. Lagheden C, Eklund C, Lamin H, Kleppe SN, Lei J, Elfström KM, et al. Nationwide comprehensive human papillomavirus (HPV) genotyping of invasive cervical cancer. british journal of cancer. 2018;118(10):1377-81. [DOI:10.1038/s41416-018-0053-6] [PMID] [PMCID]
14. Wang Y, Wang S, Shen J, Peng Y, Chen L, Mai R, et al. Genotype Distribution of Human Papillomavirus among Women with Cervical Cytological Abnormalities or Invasive Squamous Cell Carcinoma in a High-Incidence Area of Esophageal Carcinoma in China. Biomed Res Int. 2016;2016:1256384. [DOI:10.1155/2016/1256384] [PMID] [PMCID]
15. Awua AK, Sackey ST, Osei YD, Asmah RH, Wiredu EK. Prevalence of human papillomavirus genotypes among women with cervical cancer in Ghana. Infect Agent Cancer. 2016;11:4. [DOI:10.1186/s13027-016-0050-4] [PMID] [PMCID]
16. Volpini LPB, Boldrini NAT, de Freitas LB, Miranda AE, Spano LC. The high prevalence of HPV and HPV16 European variants in cervical and anal samples of HIV-seropositive women with normal Pap test results. PLoS One. 2017;12(4):e0176422. [DOI:10.1371/journal.pone.0176422] [PMID] [PMCID]
17. Boyraz G, Basaran D, Salman MC, Ozgul N, Yuce K. Clinical and pathological characteristics related to parametrial involvement in clinical early-stage cervical cancer. Ginekol Pol. 2016;87(6):417-21. [DOI:10.5603/GP.2016.0018] [PMID]
18. Pérez-Caraballo AM, Suarez E, Unger ER, Palefsky JM, Panicker G, Ortiz AP. Seroprevalence of human papillomavirus (Hpv) type 6, 11, 16, 18, by anatomic site of hpv infection, in women aged 16-64 years living in the metropolitan area of San Juan, Puerto Rico. P R Health Sci J. 2018;37(1):26-31.
19. Lim JNW, Ojo AA. Barriers to utilisation of cervical cancer screening in Sub Sahara Africa: a systematic review. Eur J Cancer Care (Engl). 2017;26(1). [DOI:10.1111/ecc.12444] [PMID]
20. Mitiku I, Tefera F. Knowledge about cervical cancer and associated factors among 15-49 year old women in dessie town, northeast ethiopia. PLoS One. 2016;11(9):e0163136. [DOI:10.1371/journal.pone.0163136] [PMID] [PMCID]
21. Setyarini E. Factors Associated with the Incidence of Cervical Cancer in RSUD Dr. Moewardi Surakarta. Univ Muhammadiyah Surakarta. 2019.
22. Haryani S, Defrin D, Yenita Y. Cervical Cancer Prevalence Based on Parity in RSUP. Dr. M. Djamil Padang Period January 2011-December 2012. Andalas Medical Journal. 2016 Sep 1;5(3). [DOI:10.25077/jka.v5i3.592]
23. Liu Y, Xin H, Xu S, Qu J, Wang Y, DiaoX-Li, et al. Epidemiology and genotype distribution of high risk human papillomavirus in population of hospital opportunistic screening. Int J Clin Exp Med. 2015;8(9):16007-16014.
24. Morris BJ, Hankins CA, Banerjee J, Lumbers ER, Mindel A, Klausner JD, et al. Does male circumcision reduce women's risk of sexually transmitted infections, cervical cancer, and associated conditions? Front Public Health. 2019;7:4. [DOI:10.3389/fpubh.2019.00004] [PMID] [PMCID]
25. Zidi S, Sahli M, Mezlini A, Yacoubli-Loueslati B. Association of Combined Tobacco Smoking, Hormonal Contraceptive use and Status Matrimonial with Cervical Cancer Evolution in Tunisian Women. Pathol Oncol Res. 2020;26(1):217-222. [DOI:10.1007/s12253-018-0442-4] [PMID]
26. Oh HY, Kim MK, Seo SS, Lee JK. Association of combined tobacco smoking and oral contraceptive use with cervical intraepithelial neoplasia 2 or 3 in Korean women. J Epidemiol. 2016;26(1):22-29. [DOI:10.2188/jea.JE20150047] [PMID] [PMCID]
27. Eleje GU, Eke AC, Igberase GO, Igwegbe AO, Eleje LI. Palliative interventions for controlling vaginal bleeding in advanced cervical cancer. Cochrane Database Syst Rev. 2015(5):CD011000. [DOI:10.1002/14651858.CD011000.pub2] [PMID] [PMCID]

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