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Khorrami M S, Sadabadi F, Pasdar A, Safarian-Bana H, Amerizadeh F, Esmaeily H, et al . A Genetic Variant in Proline and Serine Rich Coiled-Coil 1 Gene Is Associated with the Risk of Cardiovascular Disease. rbmb.net 2022; 10 (4) :653-663
URL: http://rbmb.net/article-1-759-en.html
URL: http://rbmb.net/article-1-759-en.html
Mohammad Sadegh Khorrami 
, Fatemeh Sadabadi , Alireza Pasdar , Hamide Safarian-Bana , Forouzan Amerizadeh , Habibollah Esmaeily , Mohsen Moohebati , Alireza Heidari-Bakavoli , Gordon Ferns , Majid Ghayour-Mobarhan * , Amir Avan
, Fatemeh Sadabadi , Alireza Pasdar , Hamide Safarian-Bana , Forouzan Amerizadeh , Habibollah Esmaeily , Mohsen Moohebati , Alireza Heidari-Bakavoli , Gordon Ferns , Majid Ghayour-Mobarhan * , Amir Avan
Metabolic Syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (2572 Views)
Background: Cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. The Proline and Serine Rich Coiled-Coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to investigate the association between the rs599839 polymorphism of the Proline and Serine Rich Coiled-Coil 1 (PSRC1) gene with CVD outcomes in a population sample recruited as part of the Mashhad-Stroke and Heart-Atherosclerotic-Disorders (MASHAD) cohort.
Methods: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.
Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.
Conclusions: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.
Methods: Five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the MASHAD cohort. DNA was extracted and genotyped using the TaqMan-real-time-PCR based method.
Results: The study found individuals with GA/GG genotypes were at a higher risk of CVDs (OR= 4.7; 95% CI, 2.5-8.7; p< 0.001) in comparison to those with AA genotype; however, the result was not significant for GG genotype data.
Conclusions: The results suggest that the GA/GG genotypes of the PSRC1gene locus were at increased risk of CVD in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.
Type of Article: Original Article |
Subject:
Molecular Biology
Received: 2021/07/28 | Accepted: 2021/09/6 | Published: 2022/02/7
Received: 2021/07/28 | Accepted: 2021/09/6 | Published: 2022/02/7
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