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Department of Chemistry, Ibn Al-Haitham, University of Baghdad, Baghdad 61023, Iraq
Abstract:   (20 Views)
Background: Recent research indicates that persistent inflammatory responses may contribute to the rise of diabetic nephropathy (DN) and diabetic cardiovascular disease (DCVD) in type 2 diabetes mellitus patients (DM2). Numerous molecules associated with inflammation and angiogenesis have been implicated in the development and progression of DN and DCVD, respectively.

Methods: The subjects were separated into five groups: healthy controls (n= 25), type 2 diabetes mellitus patients (n= 30), type 2 diabetes mellitus patients with nephropathy DN (n= 30), and type 2 diabetes mellitus patients with cardiovascular disease DCVD (n= 30). The blood levels of irisin, IL-8, HbA1C, urea, and creatinine were determined.

Results: In current study there was high significant increased irisin levels (p< 0.001) in DN patients than other groups and a high significant decreased IL-8 level in DCVD.

Conclusions: Serum IL-8 and irisin levels may serve as early indicators of DM2 problems (DN, DCVD).
Keywords: DM2, DN, DCVD, HbA1C, IL-8, Irisin
Full-Text [PDF 190 kb]   (10 Downloads)    
Type of Article: Original Article | Subject: Biochemistry
Received: 2022/03/29 | Accepted: 2022/03/29

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